Applying Non-canonical Redox Cofactors in Fermentation Processes
Summary: Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield of a conversion can only be approached if all electrons present in the substrate end up in the product. Control over the electrons i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220306635 |
| _version_ | 1828868427326947328 |
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| author | Ruud A. Weusthuis Pauline L. Folch Ana Pozo-Rodríguez Caroline E. Paul |
| author_facet | Ruud A. Weusthuis Pauline L. Folch Ana Pozo-Rodríguez Caroline E. Paul |
| author_sort | Ruud A. Weusthuis |
| collection | DOAJ |
| description | Summary: Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield of a conversion can only be approached if all electrons present in the substrate end up in the product. Control over the electrons is therefore crucial. However, electron transfer via redox cofactors results in a diffuse distribution of electrons over metabolism. To overcome this challenge, we propose to apply non-canonical redox cofactors (NRCs) in metabolic networks: cofactors that channel electrons exclusively from substrate to product, forming orthogonal circuits for electron transfer. |
| first_indexed | 2024-12-13T05:30:52Z |
| format | Article |
| id | doaj.art-ed734e110efa45068dc86c07e61268f7 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-13T05:30:52Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-ed734e110efa45068dc86c07e61268f72022-12-21T23:58:04ZengElsevieriScience2589-00422020-09-01239101471Applying Non-canonical Redox Cofactors in Fermentation ProcessesRuud A. Weusthuis0Pauline L. Folch1Ana Pozo-Rodríguez2Caroline E. Paul3Bioprocess Engineering, Wageningen University & Research, Post Office Box 16, 6700 AA Wageningen, the Netherlands; Corresponding authorBioprocess Engineering, Wageningen University & Research, Post Office Box 16, 6700 AA Wageningen, the NetherlandsBioprocess Engineering, Wageningen University & Research, Post Office Box 16, 6700 AA Wageningen, the NetherlandsBiocatalysis, Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, the NetherlandsSummary: Fermentation processes are used to sustainably produce chemicals and as such contribute to the transition to a circular economy. The maximum theoretical yield of a conversion can only be approached if all electrons present in the substrate end up in the product. Control over the electrons is therefore crucial. However, electron transfer via redox cofactors results in a diffuse distribution of electrons over metabolism. To overcome this challenge, we propose to apply non-canonical redox cofactors (NRCs) in metabolic networks: cofactors that channel electrons exclusively from substrate to product, forming orthogonal circuits for electron transfer.http://www.sciencedirect.com/science/article/pii/S2589004220306635MicrobiologyBiotechnologyMetabolic Engineering |
| spellingShingle | Ruud A. Weusthuis Pauline L. Folch Ana Pozo-Rodríguez Caroline E. Paul Applying Non-canonical Redox Cofactors in Fermentation Processes iScience Microbiology Biotechnology Metabolic Engineering |
| title | Applying Non-canonical Redox Cofactors in Fermentation Processes |
| title_full | Applying Non-canonical Redox Cofactors in Fermentation Processes |
| title_fullStr | Applying Non-canonical Redox Cofactors in Fermentation Processes |
| title_full_unstemmed | Applying Non-canonical Redox Cofactors in Fermentation Processes |
| title_short | Applying Non-canonical Redox Cofactors in Fermentation Processes |
| title_sort | applying non canonical redox cofactors in fermentation processes |
| topic | Microbiology Biotechnology Metabolic Engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220306635 |
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