Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A
In patients with hepatitis E virus (HEV) infections, extrahepatic, particularly renal and hematological manifestations, are increasingly reported in the medical literature but have never been studied compared to a control cohort. We retrospectively analyzed medical records of consecutive patients th...
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| Idioma: | English |
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MDPI AG
2021-01-01
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| coleção: | Pathogens |
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| Acesso em linha: | https://www.mdpi.com/2076-0817/10/1/60 |
| _version_ | 1827602009781436416 |
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| author | Thomas Theo Brehm Omid Mazaheri Thomas Horvatits Marc Lütgehetmann Julian Schulze zur Wiesch Ansgar W. Lohse Susanne Polywka Sven Pischke |
| author_facet | Thomas Theo Brehm Omid Mazaheri Thomas Horvatits Marc Lütgehetmann Julian Schulze zur Wiesch Ansgar W. Lohse Susanne Polywka Sven Pischke |
| author_sort | Thomas Theo Brehm |
| collection | DOAJ |
| description | In patients with hepatitis E virus (HEV) infections, extrahepatic, particularly renal and hematological manifestations, are increasingly reported in the medical literature but have never been studied compared to a control cohort. We retrospectively analyzed medical records of consecutive patients that were diagnosed with acute hepatitis E (AHE) (n = 69) or acute hepatitis A (AHA) (n = 46) at the University Medical Center Hamburg Eppendorf from January 2009 to August 2019 for demographical, clinical, and laboratory information. Patients with AHE had significantly lower median levels of ALAT (798 U/L) and total bilirubin (1.8 mg/dL) compared to patients with AHA (2326 U/L; <i>p</i> < 0.001 and 5.2 mg/dL; <i>p</i> < 0.001), suggesting a generally less severe hepatitis. In contrast, patients with AHE had significantly higher median serum creatinine levels (0.9 mg/dL vs. 0.8 mg/dL; <i>p</i> = 0.002) and lower median estimated glomerular filtration rate (eGFR) (91 mL/min/1.73 m<sup>2</sup> vs. 109 mL/min/1.73 m<sup>2</sup>; <i>p</i> < 0.001) than patients with AHA. Leucocyte, neutrophil and lymphocyte count, hemoglobin, platelets, red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and RDW to lymphocyte ratio (RLR) did not differ between patients with AHE and those with AHA. Our observations indicate that renal but not hematological interference presents an underrecognized extrahepatic feature of AHE, while inflammation of the liver seems to be more severe in AHA. |
| first_indexed | 2024-03-09T05:09:34Z |
| format | Article |
| id | doaj.art-ed738b276615458987893a1d03cd811c |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T05:09:34Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-ed738b276615458987893a1d03cd811c2023-12-03T12:51:50ZengMDPI AGPathogens2076-08172021-01-011016010.3390/pathogens10010060Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis AThomas Theo Brehm0Omid Mazaheri1Thomas Horvatits2Marc Lütgehetmann3Julian Schulze zur Wiesch4Ansgar W. Lohse5Susanne Polywka6Sven Pischke7Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyDepartment of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyDepartment of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, GermanyDepartment of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyDepartment of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyDepartment of Internal Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyIn patients with hepatitis E virus (HEV) infections, extrahepatic, particularly renal and hematological manifestations, are increasingly reported in the medical literature but have never been studied compared to a control cohort. We retrospectively analyzed medical records of consecutive patients that were diagnosed with acute hepatitis E (AHE) (n = 69) or acute hepatitis A (AHA) (n = 46) at the University Medical Center Hamburg Eppendorf from January 2009 to August 2019 for demographical, clinical, and laboratory information. Patients with AHE had significantly lower median levels of ALAT (798 U/L) and total bilirubin (1.8 mg/dL) compared to patients with AHA (2326 U/L; <i>p</i> < 0.001 and 5.2 mg/dL; <i>p</i> < 0.001), suggesting a generally less severe hepatitis. In contrast, patients with AHE had significantly higher median serum creatinine levels (0.9 mg/dL vs. 0.8 mg/dL; <i>p</i> = 0.002) and lower median estimated glomerular filtration rate (eGFR) (91 mL/min/1.73 m<sup>2</sup> vs. 109 mL/min/1.73 m<sup>2</sup>; <i>p</i> < 0.001) than patients with AHA. Leucocyte, neutrophil and lymphocyte count, hemoglobin, platelets, red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and RDW to lymphocyte ratio (RLR) did not differ between patients with AHE and those with AHA. Our observations indicate that renal but not hematological interference presents an underrecognized extrahepatic feature of AHE, while inflammation of the liver seems to be more severe in AHA.https://www.mdpi.com/2076-0817/10/1/60hepatitis EHEVextrahepatic manifestationsrenal impairmentserum creatinineeGFR |
| spellingShingle | Thomas Theo Brehm Omid Mazaheri Thomas Horvatits Marc Lütgehetmann Julian Schulze zur Wiesch Ansgar W. Lohse Susanne Polywka Sven Pischke Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A Pathogens hepatitis E HEV extrahepatic manifestations renal impairment serum creatinine eGFR |
| title | Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A |
| title_full | Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A |
| title_fullStr | Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A |
| title_full_unstemmed | Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A |
| title_short | Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A |
| title_sort | lower levels of transaminases but higher levels of serum creatinine in patients with acute hepatitis e in comparison to patients with hepatitis a |
| topic | hepatitis E HEV extrahepatic manifestations renal impairment serum creatinine eGFR |
| url | https://www.mdpi.com/2076-0817/10/1/60 |
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