Fatigue, Sleep, and Autoimmune and Related Disorders
Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis. Fatigue is multi-faceted and broadly defin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01827/full |
| _version_ | 1818451304517730304 |
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| author | Mark R. Zielinski Mark R. Zielinski David M. Systrom David M. Systrom Noel R. Rose |
| author_facet | Mark R. Zielinski Mark R. Zielinski David M. Systrom David M. Systrom Noel R. Rose |
| author_sort | Mark R. Zielinski |
| collection | DOAJ |
| description | Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis. Fatigue is multi-faceted and broadly defined, which makes understanding the cause of its manifestations especially difficult in conditions with diverse pathology including autoimmune diseases. In general, fatigue is defined by debilitating periods of exhaustion that interfere with normal activities. The severity and duration of fatigue episodes vary, but fatigue can cause difficulty for even simple tasks like climbing stairs or crossing the room. The exact mechanisms of fatigue are not well-understood, perhaps due to its broad definition. Nevertheless, physiological processes known to play a role in fatigue include oxygen/nutrient supply, metabolism, mood, motivation, and sleepiness—all which are affected by inflammation. Additionally, an important contributing element to fatigue is the central nervous system—a region impacted either directly or indirectly in numerous autoimmune and related disorders. This review describes how inflammation and the central nervous system contribute to fatigue and suggests potential mechanisms involved in fatigue that are likely exhibited in autoimmune and related diseases. |
| first_indexed | 2024-12-14T21:05:04Z |
| format | Article |
| id | doaj.art-ed73d20704fa4a91838357828effab18 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T21:05:04Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ed73d20704fa4a91838357828effab182022-12-21T22:47:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-08-011010.3389/fimmu.2019.01827473648Fatigue, Sleep, and Autoimmune and Related DisordersMark R. Zielinski0Mark R. Zielinski1David M. Systrom2David M. Systrom3Noel R. Rose4Veterans Affairs Boston Healthcare System, Boston, MA, United StatesDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesDepartment of Medicine, Harvard Medical School, Boston, MA, United StatesDepartment of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, United StatesDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United StatesProfound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis. Fatigue is multi-faceted and broadly defined, which makes understanding the cause of its manifestations especially difficult in conditions with diverse pathology including autoimmune diseases. In general, fatigue is defined by debilitating periods of exhaustion that interfere with normal activities. The severity and duration of fatigue episodes vary, but fatigue can cause difficulty for even simple tasks like climbing stairs or crossing the room. The exact mechanisms of fatigue are not well-understood, perhaps due to its broad definition. Nevertheless, physiological processes known to play a role in fatigue include oxygen/nutrient supply, metabolism, mood, motivation, and sleepiness—all which are affected by inflammation. Additionally, an important contributing element to fatigue is the central nervous system—a region impacted either directly or indirectly in numerous autoimmune and related disorders. This review describes how inflammation and the central nervous system contribute to fatigue and suggests potential mechanisms involved in fatigue that are likely exhibited in autoimmune and related diseases.https://www.frontiersin.org/article/10.3389/fimmu.2019.01827/fullautoimmunecytokinesfatigueinflammasomeinflammationsleep |
| spellingShingle | Mark R. Zielinski Mark R. Zielinski David M. Systrom David M. Systrom Noel R. Rose Fatigue, Sleep, and Autoimmune and Related Disorders Frontiers in Immunology autoimmune cytokines fatigue inflammasome inflammation sleep |
| title | Fatigue, Sleep, and Autoimmune and Related Disorders |
| title_full | Fatigue, Sleep, and Autoimmune and Related Disorders |
| title_fullStr | Fatigue, Sleep, and Autoimmune and Related Disorders |
| title_full_unstemmed | Fatigue, Sleep, and Autoimmune and Related Disorders |
| title_short | Fatigue, Sleep, and Autoimmune and Related Disorders |
| title_sort | fatigue sleep and autoimmune and related disorders |
| topic | autoimmune cytokines fatigue inflammasome inflammation sleep |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01827/full |
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