Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance
Cytomegalovirus (CMV) is a ubiquitous virus which causes a mild illness in healthy individuals. In immunocompromised individuals, such as children receiving haematopoietic stem cell transplantation, CMV can reactivate, causing serious disease and increasing the risk of death. CMV can be effectively...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1180392/full |
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| author | Jocelyn Hume Jocelyn Hume Emma L. Sweeney Kym Lowry Chris Fraser Julia E. Clark David M. Whiley David M. Whiley Adam D. Irwin Adam D. Irwin |
| author_facet | Jocelyn Hume Jocelyn Hume Emma L. Sweeney Kym Lowry Chris Fraser Julia E. Clark David M. Whiley David M. Whiley Adam D. Irwin Adam D. Irwin |
| author_sort | Jocelyn Hume |
| collection | DOAJ |
| description | Cytomegalovirus (CMV) is a ubiquitous virus which causes a mild illness in healthy individuals. In immunocompromised individuals, such as children receiving haematopoietic stem cell transplantation, CMV can reactivate, causing serious disease and increasing the risk of death. CMV can be effectively treated with antiviral drugs, but antiviral resistance is an increasingly common complication. Available therapies are associated with adverse effects such as bone marrow suppression and renal impairment, making the choice of appropriate treatment challenging. New agents are emerging and require evaluation in children to establish their role. This review will discuss established and emerging diagnostic tools and treatment options for CMV, including antiviral resistant CMV, in children undergoing haematopoietic stem cell transplant. |
| first_indexed | 2024-03-13T08:03:43Z |
| format | Article |
| id | doaj.art-ed750a9d4a2f496aad295c4997005a9e |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-13T08:03:43Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ed750a9d4a2f496aad295c4997005a9e2023-06-01T09:51:04ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-05-011110.3389/fped.2023.11803921180392Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistanceJocelyn Hume0Jocelyn Hume1Emma L. Sweeney2Kym Lowry3Chris Fraser4Julia E. Clark5David M. Whiley6David M. Whiley7Adam D. Irwin8Adam D. Irwin9The University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD, AustraliaCentral Microbiology, Pathology Queensland, Brisbane, QLD, AustraliaThe University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD, AustraliaThe University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD, AustraliaBlood and Bone Marrow Transplant Program, Queensland Children’s Hospital, Brisbane, QLD, AustraliaInfection Management and Prevention Service, Queensland Children’s Hospital, Brisbane, QLD, AustraliaThe University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD, AustraliaCentral Microbiology, Pathology Queensland, Brisbane, QLD, AustraliaThe University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine, The University of Queensland, Brisbane, QLD, AustraliaInfection Management and Prevention Service, Queensland Children’s Hospital, Brisbane, QLD, AustraliaCytomegalovirus (CMV) is a ubiquitous virus which causes a mild illness in healthy individuals. In immunocompromised individuals, such as children receiving haematopoietic stem cell transplantation, CMV can reactivate, causing serious disease and increasing the risk of death. CMV can be effectively treated with antiviral drugs, but antiviral resistance is an increasingly common complication. Available therapies are associated with adverse effects such as bone marrow suppression and renal impairment, making the choice of appropriate treatment challenging. New agents are emerging and require evaluation in children to establish their role. This review will discuss established and emerging diagnostic tools and treatment options for CMV, including antiviral resistant CMV, in children undergoing haematopoietic stem cell transplant.https://www.frontiersin.org/articles/10.3389/fped.2023.1180392/fullhaematopoietic stem cell transplantcytomegalovirusantiviral resistancepediatricemerging therapies |
| spellingShingle | Jocelyn Hume Jocelyn Hume Emma L. Sweeney Kym Lowry Chris Fraser Julia E. Clark David M. Whiley David M. Whiley Adam D. Irwin Adam D. Irwin Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance Frontiers in Pediatrics haematopoietic stem cell transplant cytomegalovirus antiviral resistance pediatric emerging therapies |
| title | Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance |
| title_full | Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance |
| title_fullStr | Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance |
| title_full_unstemmed | Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance |
| title_short | Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance |
| title_sort | cytomegalovirus in children undergoing haematopoietic stem cell transplantation a diagnostic and therapeutic approach to antiviral resistance |
| topic | haematopoietic stem cell transplant cytomegalovirus antiviral resistance pediatric emerging therapies |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1180392/full |
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