Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy
Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) deg...
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| Format: | Article |
| Language: | English |
| Published: |
Guilan University of Medical Sciences
2016-03-01
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| Series: | Iranian Journal of Neurosurgery |
| Subjects: | |
| Online Access: | http://irjns.org/browse.php?a_code=A-10-100-34&slc_lang=en&sid=1 |
| _version_ | 1819047904852049920 |
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| author | Kaveh Haddadi |
| author_facet | Kaveh Haddadi |
| author_sort | Kaveh Haddadi |
| collection | DOAJ |
| description | Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the source of degeneration. The use of tissue engineering to treat disc degeneration offers a chance to control the pathological course. New methods are presently being examined and have exposed mixed results. One major way of study has been stem cell injections. We go on to define the course of stem cell-mediated modalities in treatment of degenerative lumbar disc herniation.
Methods & Materials/Patients: Literature search was performed in electronic databases PUBMED and EMBASE by means of Mesh terminologies (Nucleus pulposus, therapeutics, annulus fibrosus, intervertebral disc) and keywords (Degenerative disk disease, Stem Cells, Therapy). Results: The intervertebral disc organization, developing treatments, mesenchymal stem cells, embryonic stem cells, practice in disc degeneration were some sections that were found in analysis for study review design.
Conclusion: Mesenchymal stem cells (MSCs) have revealed potential in small animal models, nonetheless consequences in greater vertebrates have been varied. |
| first_indexed | 2024-12-21T11:07:47Z |
| format | Article |
| id | doaj.art-ed756b1c13bd47d7b35890cae3b6c665 |
| institution | Directory Open Access Journal |
| issn | 2423-6497 2423-6829 |
| language | English |
| last_indexed | 2024-12-21T11:07:47Z |
| publishDate | 2016-03-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Neurosurgery |
| spelling | doaj.art-ed756b1c13bd47d7b35890cae3b6c6652022-12-21T19:06:11ZengGuilan University of Medical SciencesIranian Journal of Neurosurgery2423-64972423-68292016-03-0114610Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell TherapyKaveh Haddadi0 Assistant Professor Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the source of degeneration. The use of tissue engineering to treat disc degeneration offers a chance to control the pathological course. New methods are presently being examined and have exposed mixed results. One major way of study has been stem cell injections. We go on to define the course of stem cell-mediated modalities in treatment of degenerative lumbar disc herniation. Methods & Materials/Patients: Literature search was performed in electronic databases PUBMED and EMBASE by means of Mesh terminologies (Nucleus pulposus, therapeutics, annulus fibrosus, intervertebral disc) and keywords (Degenerative disk disease, Stem Cells, Therapy). Results: The intervertebral disc organization, developing treatments, mesenchymal stem cells, embryonic stem cells, practice in disc degeneration were some sections that were found in analysis for study review design. Conclusion: Mesenchymal stem cells (MSCs) have revealed potential in small animal models, nonetheless consequences in greater vertebrates have been varied.http://irjns.org/browse.php?a_code=A-10-100-34&slc_lang=en&sid=1Intervertevral DiscDegenerationStem cells |
| spellingShingle | Kaveh Haddadi Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy Iranian Journal of Neurosurgery Intervertevral Disc Degeneration Stem cells |
| title | Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy |
| title_full | Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy |
| title_fullStr | Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy |
| title_full_unstemmed | Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy |
| title_short | Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy |
| title_sort | degenerative disc disease a review of cell technologies and stem cell therapy |
| topic | Intervertevral Disc Degeneration Stem cells |
| url | http://irjns.org/browse.php?a_code=A-10-100-34&slc_lang=en&sid=1 |
| work_keys_str_mv | AT kavehhaddadi degenerativediscdiseaseareviewofcelltechnologiesandstemcelltherapy |