Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications
A technology platform based on a remotely controlled and stepwise transport of an array arrangement of superparamagnetic beads (SPB) for efficient molecular uptake, delivery and accumulation in the context of highly specific and sensitive analyte molecule detection for the application in lab-on-a-ch...
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| Format: | Article |
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MDPI AG
2015-11-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/15/11/28854 |
| _version_ | 1811183894292070400 |
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| author | Arno Ehresmann Iris Koch Dennis Holzinger |
| author_facet | Arno Ehresmann Iris Koch Dennis Holzinger |
| author_sort | Arno Ehresmann |
| collection | DOAJ |
| description | A technology platform based on a remotely controlled and stepwise transport of an array arrangement of superparamagnetic beads (SPB) for efficient molecular uptake, delivery and accumulation in the context of highly specific and sensitive analyte molecule detection for the application in lab-on-a-chip devices is presented. The near-surface transport of SPBs is realized via the dynamic transformation of the SPBs’ magnetic potential energy landscape above a magnetically stripe patterned Exchange-Bias (EB) thin film layer systems due to the application of sub-mT external magnetic field pulses. In this concept, the SPB velocity is dramatically influenced by the magnitude and gradient of the magnetic field landscape (MFL) above the magnetically stripe patterned EB substrate, the SPB to substrate distance, the magnetic properties of both the SPBs and the EB layer system, respectively, as well as by the properties of the external magnetic field pulses and the surrounding fluid. The focus of this review is laid on the specific MFL design in EB layer systems via light-ion bombardment induced magnetic patterning (IBMP). A numerical approach is introduced for the theoretical description of the MFL in comparison to experimental characterization via scanning Hall probe microscopy. The SPB transport mechanism will be outlined in terms of the dynamic interplay between the EB substrate’s MFL and the pulse scheme of the external magnetic field. |
| first_indexed | 2024-04-11T13:04:23Z |
| format | Article |
| id | doaj.art-ed76239c02ed414a936dd54ab7693539 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T13:04:23Z |
| publishDate | 2015-11-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj.art-ed76239c02ed414a936dd54ab76935392022-12-22T04:22:50ZengMDPI AGSensors1424-82202015-11-011511288542888810.3390/s151128854s151128854Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing ApplicationsArno Ehresmann0Iris Koch1Dennis Holzinger2Institute of Physics and Center for Interdisciplinary Nanostructure Science and Technology (CINSaT), University of Kassel, Heinrich-Plett-Str.40, Kassel D-34132, GermanyInstitute of Physics and Center for Interdisciplinary Nanostructure Science and Technology (CINSaT), University of Kassel, Heinrich-Plett-Str.40, Kassel D-34132, GermanyInstitute of Physics and Center for Interdisciplinary Nanostructure Science and Technology (CINSaT), University of Kassel, Heinrich-Plett-Str.40, Kassel D-34132, GermanyA technology platform based on a remotely controlled and stepwise transport of an array arrangement of superparamagnetic beads (SPB) for efficient molecular uptake, delivery and accumulation in the context of highly specific and sensitive analyte molecule detection for the application in lab-on-a-chip devices is presented. The near-surface transport of SPBs is realized via the dynamic transformation of the SPBs’ magnetic potential energy landscape above a magnetically stripe patterned Exchange-Bias (EB) thin film layer systems due to the application of sub-mT external magnetic field pulses. In this concept, the SPB velocity is dramatically influenced by the magnitude and gradient of the magnetic field landscape (MFL) above the magnetically stripe patterned EB substrate, the SPB to substrate distance, the magnetic properties of both the SPBs and the EB layer system, respectively, as well as by the properties of the external magnetic field pulses and the surrounding fluid. The focus of this review is laid on the specific MFL design in EB layer systems via light-ion bombardment induced magnetic patterning (IBMP). A numerical approach is introduced for the theoretical description of the MFL in comparison to experimental characterization via scanning Hall probe microscopy. The SPB transport mechanism will be outlined in terms of the dynamic interplay between the EB substrate’s MFL and the pulse scheme of the external magnetic field.http://www.mdpi.com/1424-8220/15/11/28854Exchange-Biasion bombardment induced magnetic patterning (IBMP)magnetic stray fieldsmagnetic field landscape designsuperparamagnetic beadparticle transportpotential energy landscapebiosensorDOWMATmicrofluid mixingscanning Hall probe microscopy |
| spellingShingle | Arno Ehresmann Iris Koch Dennis Holzinger Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications Sensors Exchange-Bias ion bombardment induced magnetic patterning (IBMP) magnetic stray fields magnetic field landscape design superparamagnetic bead particle transport potential energy landscape biosensor DOWMAT microfluid mixing scanning Hall probe microscopy |
| title | Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications |
| title_full | Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications |
| title_fullStr | Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications |
| title_full_unstemmed | Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications |
| title_short | Manipulation of Superparamagnetic Beads on Patterned Exchange-Bias Layer Systems for Biosensing Applications |
| title_sort | manipulation of superparamagnetic beads on patterned exchange bias layer systems for biosensing applications |
| topic | Exchange-Bias ion bombardment induced magnetic patterning (IBMP) magnetic stray fields magnetic field landscape design superparamagnetic bead particle transport potential energy landscape biosensor DOWMAT microfluid mixing scanning Hall probe microscopy |
| url | http://www.mdpi.com/1424-8220/15/11/28854 |
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