Therapeutic Effect of the Correction of Vitamin D Deficiency in Patients with Benign Paroxysmal Positional Vertigo. A Randomized Clinical Trial
Introduction Benign paroxysmal positional vertigo (BPPV) appears during the same age group in which vitamin D and calcium deficiencies are evident. Vitamin D deficiency could predispose to BPPV, since these two entities share a demineralization process. Objective To establish the otologic...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações Ltda.
2022-10-01
|
| Series: | International Archives of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1730992 |
| _version_ | 1797988796444180480 |
|---|---|
| author | Jimena Mancera Sánchez Juan Carlos Hernaiz Leonardo Julia Kioko Ishiwara Niembro Juan Carlos Lesser |
| author_facet | Jimena Mancera Sánchez Juan Carlos Hernaiz Leonardo Julia Kioko Ishiwara Niembro Juan Carlos Lesser |
| author_sort | Jimena Mancera Sánchez |
| collection | DOAJ |
| description | Introduction Benign paroxysmal positional vertigo (BPPV) appears during the same age group in which vitamin D and calcium deficiencies are evident. Vitamin D deficiency could predispose to BPPV, since these two entities share a demineralization process.
Objective To establish the otological impact of vitamin D supplementation in patients with its deficiency who suffer from BPPV.
Methods This was a randomized clinical trial. A total of 35 patients with vitamin D deficiency (< 30 ng/ml) and BPPV were divided into 2 groups: Group 1 (control group): treatment with repositioning maneuvers; and Group 2: treatment with repositioning maneuvers and vitamin D supplementation.
Results A follow-up of between 6 and 13 months and a log rank test revealed that the probability of recurrence between the experimental groups was significantly different, with group 2 having a decreased recurrence of vertigo (p = 0.17). Scores in the Dizziness Handicap inventory (DHI) in patients treated with vitamin D supplementation were smaller (10 ± 9) when compared with a score of 36 ± 9 in the control group.
Conclusion Plasmatic values of 25-hydroxyvitamin D have an impact in patients with BPPV, who present an improvement in their quality of life when their vitamin D levels are replaced with supplementation. Benign paroxysmal positional vertigo could stop being perceived as a purely otologic disease. |
| first_indexed | 2024-04-11T08:09:44Z |
| format | Article |
| id | doaj.art-ed7642bf4a164094b5ddd4603ddb1b86 |
| institution | Directory Open Access Journal |
| issn | 1809-9777 1809-4864 |
| language | English |
| last_indexed | 2024-04-11T08:09:44Z |
| publishDate | 2022-10-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | International Archives of Otorhinolaryngology |
| spelling | doaj.art-ed7642bf4a164094b5ddd4603ddb1b862022-12-22T04:35:26ZengThieme Revinter Publicações Ltda.International Archives of Otorhinolaryngology1809-97771809-48642022-10-012604e666e67010.1055/s-0041-1730992Therapeutic Effect of the Correction of Vitamin D Deficiency in Patients with Benign Paroxysmal Positional Vertigo. A Randomized Clinical TrialJimena Mancera Sánchez0Juan Carlos Hernaiz Leonardo1Julia Kioko Ishiwara Niembro2Juan Carlos Lesser3Ear Nose and Throat Department, Instituto Nacional de Rehabilitación, Mexico City, MexicoEar Nose and Throat Department, Instituto Nacional de Rehabilitación, Mexico City, MexicoDepartment of Otoneurology, Instituto Nacional de Rehabilitacion Luis Guillermo Ibarra Ibarra, Mexico City, MexicoEar Nose and Throat Department, Instituto Nacional de Rehabilitación, Mexico City, MexicoIntroduction Benign paroxysmal positional vertigo (BPPV) appears during the same age group in which vitamin D and calcium deficiencies are evident. Vitamin D deficiency could predispose to BPPV, since these two entities share a demineralization process. Objective To establish the otological impact of vitamin D supplementation in patients with its deficiency who suffer from BPPV. Methods This was a randomized clinical trial. A total of 35 patients with vitamin D deficiency (< 30 ng/ml) and BPPV were divided into 2 groups: Group 1 (control group): treatment with repositioning maneuvers; and Group 2: treatment with repositioning maneuvers and vitamin D supplementation. Results A follow-up of between 6 and 13 months and a log rank test revealed that the probability of recurrence between the experimental groups was significantly different, with group 2 having a decreased recurrence of vertigo (p = 0.17). Scores in the Dizziness Handicap inventory (DHI) in patients treated with vitamin D supplementation were smaller (10 ± 9) when compared with a score of 36 ± 9 in the control group. Conclusion Plasmatic values of 25-hydroxyvitamin D have an impact in patients with BPPV, who present an improvement in their quality of life when their vitamin D levels are replaced with supplementation. Benign paroxysmal positional vertigo could stop being perceived as a purely otologic disease.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1730992benign paroxysmal positional vertigodeficiencyvitamin d |
| spellingShingle | Jimena Mancera Sánchez Juan Carlos Hernaiz Leonardo Julia Kioko Ishiwara Niembro Juan Carlos Lesser Therapeutic Effect of the Correction of Vitamin D Deficiency in Patients with Benign Paroxysmal Positional Vertigo. A Randomized Clinical Trial International Archives of Otorhinolaryngology benign paroxysmal positional vertigo deficiency vitamin d |
| title | Therapeutic Effect of the Correction of Vitamin D Deficiency in Patients with Benign Paroxysmal Positional Vertigo. A Randomized Clinical Trial |
| title_full | Therapeutic Effect of the Correction of Vitamin D Deficiency in Patients with Benign Paroxysmal Positional Vertigo. A Randomized Clinical Trial |
| title_fullStr | Therapeutic Effect of the Correction of Vitamin D Deficiency in Patients with Benign Paroxysmal Positional Vertigo. A Randomized Clinical Trial |
| title_full_unstemmed | Therapeutic Effect of the Correction of Vitamin D Deficiency in Patients with Benign Paroxysmal Positional Vertigo. A Randomized Clinical Trial |
| title_short | Therapeutic Effect of the Correction of Vitamin D Deficiency in Patients with Benign Paroxysmal Positional Vertigo. A Randomized Clinical Trial |
| title_sort | therapeutic effect of the correction of vitamin d deficiency in patients with benign paroxysmal positional vertigo a randomized clinical trial |
| topic | benign paroxysmal positional vertigo deficiency vitamin d |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1730992 |
| work_keys_str_mv | AT jimenamancerasanchez therapeuticeffectofthecorrectionofvitaminddeficiencyinpatientswithbenignparoxysmalpositionalvertigoarandomizedclinicaltrial AT juancarloshernaizleonardo therapeuticeffectofthecorrectionofvitaminddeficiencyinpatientswithbenignparoxysmalpositionalvertigoarandomizedclinicaltrial AT juliakiokoishiwaraniembro therapeuticeffectofthecorrectionofvitaminddeficiencyinpatientswithbenignparoxysmalpositionalvertigoarandomizedclinicaltrial AT juancarloslesser therapeuticeffectofthecorrectionofvitaminddeficiencyinpatientswithbenignparoxysmalpositionalvertigoarandomizedclinicaltrial |