Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology.

Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology.

Numerous lines of evidence point to a genetic basis for facial morphology in humans, yet little is known about how specific genetic variants relate to the phenotypic expression of many common facial features. We conducted genome-wide association meta-analyses of 20 quantitative facial measurements d...

Full description

Bibliographic Details
Main Authors:	John R Shaffer, Ekaterina Orlova, Myoung Keun Lee, Elizabeth J Leslie, Zachary D Raffensperger, Carrie L Heike, Michael L Cunningham, Jacqueline T Hecht, Chung How Kau, Nichole L Nidey, Lina M Moreno, George L Wehby, Jeffrey C Murray, Cecelia A Laurie, Cathy C Laurie, Joanne Cole, Tracey Ferrara, Stephanie Santorico, Ophir Klein, Washington Mio, Eleanor Feingold, Benedikt Hallgrimsson, Richard A Spritz, Mary L Marazita, Seth M Weinberg
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-08-01
Series:	PLoS Genetics
Online Access:	http://europepmc.org/articles/PMC4999139?pdf=render

Similar Items

Let's face it--complex traits are just not that simple.
by: Benedikt Hallgrimsson, et al.
Published: (2014-11-01)

Genome-wide Interaction Study Implicates VGLL2 and Alcohol Exposure and PRL and Smoking in Orofacial Cleft Risk
by: Jenna C. Carlson, et al.
Published: (2022-02-01)

Mapping genetic variants for cranial vault shape in humans.
by: Jasmien Roosenboom, et al.
Published: (2018-01-01)

PRICKLE1 × FOCAD Interaction Revealed by Genome-Wide vQTL Analysis of Human Facial Traits
by: Dongjing Liu, et al.
Published: (2021-08-01)

SNPs Associated With Testosterone Levels Influence Human Facial Morphology
by: Jasmien Roosenboom, et al.
Published: (2018-10-01)

Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.
by: Joanne B Cole, et al.
Published: (2016-08-01)

Impact of low-frequency coding variants on human facial shape
by: Dongjing Liu, et al.
Published: (2021-01-01)

Genome-Wide Association Study of Non-syndromic Orofacial Clefts in a Multiethnic Sample of Families and Controls Identifies Novel Regions
by: Nandita Mukhopadhyay, et al.
Published: (2021-04-01)

Bent pinkies: Quantifying fifth finger clinodactyly in a sample of U.S. adults.
by: Myoung Keun Lee, et al.
Published: (2022-01-01)

Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations.
by: Chenxing Liu, et al.
Published: (2021-08-01)

Genome-wide analysis of copy number variants and normal facial variation in a large cohort of Bantu Africans
by: Megan Null, et al.
Published: (2022-01-01)

Six NSCL/P Loci Show Associations With Normal-Range Craniofacial Variation
by: Karlijne Indencleef, et al.
Published: (2018-10-01)

Early-onset autoimmune vitiligo associated with an enhancer variant haplotype that upregulates class II HLA expression
by: Ying Jin, et al.
Published: (2019-01-01)

Genome-wide copy number variations in a large cohort of bantu African children
by: Feyza Yilmaz, et al.
Published: (2021-05-01)

Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort
by: Rasha N. Alotaibi, et al.
Published: (2022-01-01)

Avançando e priorizando a pesquisa sobre fissuras orais no Brasil Advancing and prioritizing research on oral clefts in Brazil
by: George L. Wehby
Published: (2013-04-01)

Avançando e priorizando a pesquisa sobre fissuras orais no Brasil
by: George L. Wehby
Published: (2013-04-01)

Advancing and prioritizing research on oral clefts in Brazil
by: George L. Wehby
Published: (2013-03-01)

Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions
by: Tianyu Zou, et al.
Published: (2023-03-01)

The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation
by: Karlijne Indencleef, et al.
Published: (2021-02-01)

Detecting Gene-Environment Interaction for Maternal Exposures Using Case-Parent Trios Ascertained Through a Case With Non-Syndromic Orofacial Cleft
by: Wanying Zhang, et al.
Published: (2021-04-01)

Large-scale open-source three-dimensional growth curves for clinical facial assessment and objective description of facial dysmorphism
by: Harold S. Matthews, et al.
Published: (2021-06-01)

Lack of mutations in the PVRL3 gene in North American caucasians with non-syndromic cleft lip/palate
by: Mehmet A. Sözen, et al.
Published: (2008-01-01)

Mutation and association analysis of the PVR and PVRL2 genes in patients with non-syndromic cleft lip and palate
by: Mehmet A. Sözen, et al.
Published: (2009-01-01)

Revisiting the effects of state earned income tax credits on infant health: a quasi-experimental study using contiguous border counties approach
by: Haobing Qian, et al.
Published: (2023-12-01)

Runaway Rulers: Marriage, Power, and Building a Wider Medieval Europe
by: Christian Raffensperger
Published: (2021-12-01)

Heritability of face shape in twins: a preliminary study using 3D stereophotogrammetry and geometric morphometrics
by: Seth M. Weinberg, et al.
Published: (2013-11-01)

Arnfried Antonius, coral diseases, and the AMLC
by: Laurie L. Richardson
Published: (2012-03-01)

Arnfried Antonius, coral diseases, and the AMLC
by: Laurie L. Richardson
Published: (2012-03-01)

Dental anomaly detection using intraoral photos via deep learning
by: Ronilo Ragodos, et al.
Published: (2022-07-01)

Author Correction: Dental anomaly detection using intraoral photos via deep learning
by: Ronilo Ragodos, et al.
Published: (2022-08-01)

A price on warming with a supply chain directed market
by: John F. Raffensperger
Published: (2021-02-01)

Correction : A price on warming with a supply chain directed market
by: John F. Raffensperger
Published: (2024-04-01)

Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies and Transcriptome-Wide Association Study
by: Ekaterina Orlova, et al.
Published: (2022-12-01)

Aspects of cheetah (Acinonyx jubatus) biology, ecology and conservation strategies on Namibian farmlands
by: Marker, L, et al.
Published: (2002)

Managing software requirements : organizational and political challenges
by: Rodriguez, Laurie L., 1976-
Published: (2005)

First trimester prenatal screening biomarkers and gestational diabetes mellitus: A systematic review and meta-analysis.
by: Brittney M Donovan, et al.
Published: (2018-01-01)

Fully Automatic Landmarking of Syndromic 3D Facial Surface Scans Using 2D Images
by: Jordan J. Bannister, et al.
Published: (2020-06-01)

Association signals unveiled by a comprehensive gene set enrichment analysis of dental caries genome-wide association studies.
by: Quan Wang, et al.
Published: (2013-01-01)

Genome-Wide Association Study (GWAS) of dental caries in diverse populations
by: Rasha N. Alotaibi, et al.
Published: (2021-07-01)