Cancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironment
Abstract Cancer-associated fibroblasts (CAFs) are the most abundant stromal cells within the tumor microenvironment (TME). They extensively communicate with the other cells. Exosome-packed bioactive molecules derived from CAFs can reshape the TME by interacting with other cells and the extracellular...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-05-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10020-023-00665-y |
| _version_ | 1797817951145951232 |
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| author | Zhiwei Peng Zhiwei Tong Zihao Ren Manping Ye Kongwang Hu |
| author_facet | Zhiwei Peng Zhiwei Tong Zihao Ren Manping Ye Kongwang Hu |
| author_sort | Zhiwei Peng |
| collection | DOAJ |
| description | Abstract Cancer-associated fibroblasts (CAFs) are the most abundant stromal cells within the tumor microenvironment (TME). They extensively communicate with the other cells. Exosome-packed bioactive molecules derived from CAFs can reshape the TME by interacting with other cells and the extracellular matrix, which adds a new perspective for their clinical application in tumor targeted therapy. An in-depth understanding of the biological characteristics of CAF-derived exosomes (CDEs) is critical for depicting the detailed landscape of the TME and developing tailored therapeutic strategies for cancer treatment. In this review, we have summarized the functional roles of CAFs in the TME, particularly focusing on the extensive communication mediated by CDEs that contain biological molecules such as miRNAs, proteins, metabolites, and other components. In addition, we have also highlighted the prospects for diagnostic and therapeutic applications based on CDEs, which could guide the future development of exosome-targeted anti-tumor drugs. |
| first_indexed | 2024-03-13T09:00:56Z |
| format | Article |
| id | doaj.art-ed76a05a6fc04cf5a747f038cc60de00 |
| institution | Directory Open Access Journal |
| issn | 1528-3658 |
| language | English |
| last_indexed | 2024-03-13T09:00:56Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-ed76a05a6fc04cf5a747f038cc60de002023-05-28T11:19:41ZengBMCMolecular Medicine1528-36582023-05-0129112410.1186/s10020-023-00665-yCancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironmentZhiwei Peng0Zhiwei Tong1Zihao Ren2Manping Ye3Kongwang Hu4Department of General Surgery, First Affiliated Hospital of Anhui Medical UniversityDepartment of General Surgery, First Affiliated Hospital of Anhui Medical UniversityDepartment of General Surgery, First Affiliated Hospital of Anhui Medical UniversityAnhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical UniversityDepartment of General Surgery, First Affiliated Hospital of Anhui Medical UniversityAbstract Cancer-associated fibroblasts (CAFs) are the most abundant stromal cells within the tumor microenvironment (TME). They extensively communicate with the other cells. Exosome-packed bioactive molecules derived from CAFs can reshape the TME by interacting with other cells and the extracellular matrix, which adds a new perspective for their clinical application in tumor targeted therapy. An in-depth understanding of the biological characteristics of CAF-derived exosomes (CDEs) is critical for depicting the detailed landscape of the TME and developing tailored therapeutic strategies for cancer treatment. In this review, we have summarized the functional roles of CAFs in the TME, particularly focusing on the extensive communication mediated by CDEs that contain biological molecules such as miRNAs, proteins, metabolites, and other components. In addition, we have also highlighted the prospects for diagnostic and therapeutic applications based on CDEs, which could guide the future development of exosome-targeted anti-tumor drugs.https://doi.org/10.1186/s10020-023-00665-yCancer-associated fibroblastsExosomesTumor microenvironmentDiagnosisTherapy |
| spellingShingle | Zhiwei Peng Zhiwei Tong Zihao Ren Manping Ye Kongwang Hu Cancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironment Molecular Medicine Cancer-associated fibroblasts Exosomes Tumor microenvironment Diagnosis Therapy |
| title | Cancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironment |
| title_full | Cancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironment |
| title_fullStr | Cancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironment |
| title_full_unstemmed | Cancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironment |
| title_short | Cancer-associated fibroblasts and its derived exosomes: a new perspective for reshaping the tumor microenvironment |
| title_sort | cancer associated fibroblasts and its derived exosomes a new perspective for reshaping the tumor microenvironment |
| topic | Cancer-associated fibroblasts Exosomes Tumor microenvironment Diagnosis Therapy |
| url | https://doi.org/10.1186/s10020-023-00665-y |
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