Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold

Intracellular generation of gold nanoparticles has drawn attention but toxic effects have limited potential applications. Here, the authors report on the delivery of ionic gold with PEG resulting in faster synthesis and reduced toxicity due to lower concentrations of ionic gold required and explore...

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Main Authors: Aaron S. Schwartz-Duval, Christian J. Konopka, Parikshit Moitra, Enrique A. Daza, Indrajit Srivastava, Elyse V. Johnson, Taylor L. Kampert, Stanley Fayn, Anand Haran, Lawrence W. Dobrucki, Dipanjan Pan
Format: Article
Language:English
Published: Nature Portfolio 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17595-6
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author Aaron S. Schwartz-Duval
Christian J. Konopka
Parikshit Moitra
Enrique A. Daza
Indrajit Srivastava
Elyse V. Johnson
Taylor L. Kampert
Stanley Fayn
Anand Haran
Lawrence W. Dobrucki
Dipanjan Pan
author_facet Aaron S. Schwartz-Duval
Christian J. Konopka
Parikshit Moitra
Enrique A. Daza
Indrajit Srivastava
Elyse V. Johnson
Taylor L. Kampert
Stanley Fayn
Anand Haran
Lawrence W. Dobrucki
Dipanjan Pan
author_sort Aaron S. Schwartz-Duval
collection DOAJ
description Intracellular generation of gold nanoparticles has drawn attention but toxic effects have limited potential applications. Here, the authors report on the delivery of ionic gold with PEG resulting in faster synthesis and reduced toxicity due to lower concentrations of ionic gold required and explore potential applications.
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spelling doaj.art-ed78eaa00a594fb28473531f16e63f692022-12-21T21:46:32ZengNature PortfolioNature Communications2041-17232020-09-0111111810.1038/s41467-020-17595-6Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic goldAaron S. Schwartz-Duval0Christian J. Konopka1Parikshit Moitra2Enrique A. Daza3Indrajit Srivastava4Elyse V. Johnson5Taylor L. Kampert6Stanley Fayn7Anand Haran8Lawrence W. Dobrucki9Dipanjan Pan10Department of Bioengineering, University of Illinois, Urbana-ChampaignDepartment of Bioengineering, University of Illinois, Urbana-ChampaignDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland Baltimore School of MedicineDepartment of Bioengineering, University of Illinois, Urbana-ChampaignDepartment of Bioengineering, University of Illinois, Urbana-ChampaignCytoviva inc.Department of Bioengineering, University of Illinois, Urbana-ChampaignDepartment of Bioengineering, University of Illinois, Urbana-ChampaignDepartment of Bioengineering, University of Illinois, Urbana-ChampaignDepartment of Bioengineering, University of Illinois, Urbana-ChampaignDepartment of Bioengineering, University of Illinois, Urbana-ChampaignIntracellular generation of gold nanoparticles has drawn attention but toxic effects have limited potential applications. Here, the authors report on the delivery of ionic gold with PEG resulting in faster synthesis and reduced toxicity due to lower concentrations of ionic gold required and explore potential applications.https://doi.org/10.1038/s41467-020-17595-6
spellingShingle Aaron S. Schwartz-Duval
Christian J. Konopka
Parikshit Moitra
Enrique A. Daza
Indrajit Srivastava
Elyse V. Johnson
Taylor L. Kampert
Stanley Fayn
Anand Haran
Lawrence W. Dobrucki
Dipanjan Pan
Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
Nature Communications
title Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
title_full Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
title_fullStr Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
title_full_unstemmed Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
title_short Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
title_sort intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
url https://doi.org/10.1038/s41467-020-17595-6
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