A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription

A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription

Abstract The essential G1-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type cyclins are rate-limiting regulators of G1-S progression in mammalian cells via their ability to bind and activate CDK4 and CDK6. In addition, cycli...

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Main Authors: Xuanmao Jiao, Gabriele Di Sante, Mathew C. Casimiro, Agnes Tantos, Anthony W. Ashton, Zhiping Li, Yen Quach, Dharmendra Bhargava, Agnese Di Rocco, Claudia Pupo, Marco Crosariol, Tamas Lazar, Peter Tompa, Chenguang Wang, Zuoren Yu, Zhao Zhang, Kawthar Aldaaysi, Ratna Vadlamudi, Monica Mann, Emmanuel Skordalakes, Andrew Kossenkov, Yanming Du, Richard G. Pestell
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-023-00502-1

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