Utility of ultrasound strain elastography to differentiate benign from malignant lesions of the breast
Background: The purpose of this study was to determine the utility and diagnostic performance of strain elastography (SE) in differentiating benign from malignant lesions of the breast. Methods: In this prospective study, 50 palpable breast masses in 50 patients were examined by mammography, B-mode...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Medical Ultrasound |
| Subjects: | |
| Online Access: | http://www.jmuonline.org/article.asp?issn=0929-6441;year=2021;volume=29;issue=2;spage=89;epage=93;aulast=Kanagaraju |
| _version_ | 1818656509235560448 |
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| author | Vikrant Kanagaraju B Dhivya B Devanand V Maheswaran |
| author_facet | Vikrant Kanagaraju B Dhivya B Devanand V Maheswaran |
| author_sort | Vikrant Kanagaraju |
| collection | DOAJ |
| description | Background: The purpose of this study was to determine the utility and diagnostic performance of strain elastography (SE) in differentiating benign from malignant lesions of the breast. Methods: In this prospective study, 50 palpable breast masses in 50 patients were examined by mammography, B-mode ultrasound (US) and SE. Lesions were categorized using Breast Imaging Reporting and Data System (BIRADS) scoring based on mammographic and sonographic features. Elasticity scores were assessed on a five-point scale based on the distribution of strain, and the lesion size on SE imaging and B-mode (elasticity imaging/B mode [EI/B] ratio) was compared. Findings were correlated with the BIRADS assessment and diagnostic performance of sonoelastography was evaluated taking histopathology as reference standard. Results: Histopathology revealed 29 (58%) malignant and 21 (42%) benign lesions. Infiltrative ductal carcinoma and fibroadenoma were the most common malignant and benign lesions, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of SE was 100%, 76.1%, 85.2%, 100%, and 90%, respectively. Higher elasticity score was significantly associated with malignant histopathology (P < 0.00001). The mean EI/B ratio for malignant lesions was 1.36 ± 0.24 while that of benign lesions was 1.03 ± 0.30 (P = 0.000). Conclusion: Real-time SE of the breast, with its superior sensitivity and specificity, could provide improved characterization of benign and malignant breast masses compared with mammography and conventional US. Due to greater diagnostic accuracy, SE can be an effective adjunctive tool to B-mode US in predicting malignancy of breast, as well as in reducing the need for biopsies in benign breast lesions. |
| first_indexed | 2024-12-17T03:26:43Z |
| format | Article |
| id | doaj.art-ed7ca8e07a13455da61aec9e531e24d1 |
| institution | Directory Open Access Journal |
| issn | 0929-6441 2212-1552 |
| language | English |
| last_indexed | 2024-12-17T03:26:43Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Ultrasound |
| spelling | doaj.art-ed7ca8e07a13455da61aec9e531e24d12022-12-21T22:05:23ZengWolters Kluwer Medknow PublicationsJournal of Medical Ultrasound0929-64412212-15522021-01-01292899310.4103/JMU.JMU_32_20Utility of ultrasound strain elastography to differentiate benign from malignant lesions of the breastVikrant KanagarajuB DhivyaB DevanandV MaheswaranBackground: The purpose of this study was to determine the utility and diagnostic performance of strain elastography (SE) in differentiating benign from malignant lesions of the breast. Methods: In this prospective study, 50 palpable breast masses in 50 patients were examined by mammography, B-mode ultrasound (US) and SE. Lesions were categorized using Breast Imaging Reporting and Data System (BIRADS) scoring based on mammographic and sonographic features. Elasticity scores were assessed on a five-point scale based on the distribution of strain, and the lesion size on SE imaging and B-mode (elasticity imaging/B mode [EI/B] ratio) was compared. Findings were correlated with the BIRADS assessment and diagnostic performance of sonoelastography was evaluated taking histopathology as reference standard. Results: Histopathology revealed 29 (58%) malignant and 21 (42%) benign lesions. Infiltrative ductal carcinoma and fibroadenoma were the most common malignant and benign lesions, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of SE was 100%, 76.1%, 85.2%, 100%, and 90%, respectively. Higher elasticity score was significantly associated with malignant histopathology (P < 0.00001). The mean EI/B ratio for malignant lesions was 1.36 ± 0.24 while that of benign lesions was 1.03 ± 0.30 (P = 0.000). Conclusion: Real-time SE of the breast, with its superior sensitivity and specificity, could provide improved characterization of benign and malignant breast masses compared with mammography and conventional US. Due to greater diagnostic accuracy, SE can be an effective adjunctive tool to B-mode US in predicting malignancy of breast, as well as in reducing the need for biopsies in benign breast lesions.http://www.jmuonline.org/article.asp?issn=0929-6441;year=2021;volume=29;issue=2;spage=89;epage=93;aulast=Kanagarajubreastelasticity imaging techniquesonoelastography |
| spellingShingle | Vikrant Kanagaraju B Dhivya B Devanand V Maheswaran Utility of ultrasound strain elastography to differentiate benign from malignant lesions of the breast Journal of Medical Ultrasound breast elasticity imaging technique sonoelastography |
| title | Utility of ultrasound strain elastography to differentiate benign from malignant lesions of the breast |
| title_full | Utility of ultrasound strain elastography to differentiate benign from malignant lesions of the breast |
| title_fullStr | Utility of ultrasound strain elastography to differentiate benign from malignant lesions of the breast |
| title_full_unstemmed | Utility of ultrasound strain elastography to differentiate benign from malignant lesions of the breast |
| title_short | Utility of ultrasound strain elastography to differentiate benign from malignant lesions of the breast |
| title_sort | utility of ultrasound strain elastography to differentiate benign from malignant lesions of the breast |
| topic | breast elasticity imaging technique sonoelastography |
| url | http://www.jmuonline.org/article.asp?issn=0929-6441;year=2021;volume=29;issue=2;spage=89;epage=93;aulast=Kanagaraju |
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