Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders

Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders

Background and objective: The determination of pharmacokinetic properties of new chemical entities is a key step in the process of drug development. Positron emission tomography (PET) is an ideal technique to obtain both biodistribution and pharmacokinetic parameters of new compounds over a wide ran...

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Bibliographic Details
Main Authors: Rossana Passannante, Vanessa Gómez-Vallejo, Maialen Sagartzazu-Aizpurua, Laura Vignau Arsuaga, Pablo Marco-Moreno, Garazi Aldanondo, Ainara Vallejo-Illarramendi, Pablo Aguiar, Unai Cossío, Abraham Martín, Jonas Bergare, Lee Kingston, Charles S. Elmore, Miguel Angel Morcillo, Pablo Ferrón, Jesus M. Aizpurua, Jordi Llop
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biomedicines
Subjects:
PET
radiolabelling
pharmacokinetics
Online Access:https://www.mdpi.com/2227-9059/11/2/253

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