Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional study
Objective Previous studies linking Triglyceride Glucose (TyG) Index to carotid plaque have yielded inconsistent results. Moreover, related studies on the population of Japan are rare. This study aims to provide further results.Design A hospital-based cross-sectional study.Setting The Shin Takeo Hosp...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/6/e069663.full |
| _version_ | 1797796293151555584 |
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| author | Min Ye Jiuling Liu Yuanwei Wang |
| author_facet | Min Ye Jiuling Liu Yuanwei Wang |
| author_sort | Min Ye |
| collection | DOAJ |
| description | Objective Previous studies linking Triglyceride Glucose (TyG) Index to carotid plaque have yielded inconsistent results. Moreover, related studies on the population of Japan are rare. This study aims to provide further results.Design A hospital-based cross-sectional study.Setting The Shin Takeo Hospital.Participants We assessed 1904 Japanese participants (988 men and 916 women) whose mean age was 57±11.9 years, and those participants underwent health check-ups at Shinbuf Hospital at Shin Takeo Hospital from 1 April 2016 to 31 October 2017.Methodology Carotid plaque, triglyceride and fasting glucose and other relevant indicators were collected. We used ultrasonography to evaluate carotid plaque. A multivariable logistic regression model and generalised additive model were used to evaluate the association between the TyG Index and carotid plaque. Subgroup and interaction analyses were validated for the consistency of these correlations.Results Following the adjustment of traditional carotid plaque risk factors, the non-linear relationship between the TyG Index and carotid plaque was investigated. Using a two-piecewise regression model, we calculated the inflection point to be 9.06. The OR and 95% CIs for the inflection points on the left and right sides were 1.70 (1.27 to 2.29) and 0.88 (0.52 to 1.47), respectively. According to the variables tested, the interactions between the TyG Index and all subgroup factors were analysed and significant interactions were not observed.Conclusion In individuals who underwent a comprehensive check-up in Japan, the relationship between the TyG Index and carotid plaque is non-linear. When the TyG Index is less than 9.06, it is associated with carotid plaque. |
| first_indexed | 2024-03-13T03:30:53Z |
| format | Article |
| id | doaj.art-ed7dc2570dfa430a97215d9ab1e4e66d |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-13T03:30:53Z |
| publishDate | 2023-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-ed7dc2570dfa430a97215d9ab1e4e66d2023-06-24T08:00:06ZengBMJ Publishing GroupBMJ Open2044-60552023-06-0113610.1136/bmjopen-2022-069663Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional studyMin Ye0Jiuling Liu1Yuanwei Wang21 Department of Neurology, Nanjing BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China1 Department of Neurology, Nanjing BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China2 Department of Neurology, The Affiliated Shuyang Hospital of Xuzhou Medical University, Shuyang, Jiangsu, ChinaObjective Previous studies linking Triglyceride Glucose (TyG) Index to carotid plaque have yielded inconsistent results. Moreover, related studies on the population of Japan are rare. This study aims to provide further results.Design A hospital-based cross-sectional study.Setting The Shin Takeo Hospital.Participants We assessed 1904 Japanese participants (988 men and 916 women) whose mean age was 57±11.9 years, and those participants underwent health check-ups at Shinbuf Hospital at Shin Takeo Hospital from 1 April 2016 to 31 October 2017.Methodology Carotid plaque, triglyceride and fasting glucose and other relevant indicators were collected. We used ultrasonography to evaluate carotid plaque. A multivariable logistic regression model and generalised additive model were used to evaluate the association between the TyG Index and carotid plaque. Subgroup and interaction analyses were validated for the consistency of these correlations.Results Following the adjustment of traditional carotid plaque risk factors, the non-linear relationship between the TyG Index and carotid plaque was investigated. Using a two-piecewise regression model, we calculated the inflection point to be 9.06. The OR and 95% CIs for the inflection points on the left and right sides were 1.70 (1.27 to 2.29) and 0.88 (0.52 to 1.47), respectively. According to the variables tested, the interactions between the TyG Index and all subgroup factors were analysed and significant interactions were not observed.Conclusion In individuals who underwent a comprehensive check-up in Japan, the relationship between the TyG Index and carotid plaque is non-linear. When the TyG Index is less than 9.06, it is associated with carotid plaque.https://bmjopen.bmj.com/content/13/6/e069663.full |
| spellingShingle | Min Ye Jiuling Liu Yuanwei Wang Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional study BMJ Open |
| title | Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional study |
| title_full | Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional study |
| title_fullStr | Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional study |
| title_full_unstemmed | Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional study |
| title_short | Association between Triglyceride-Glucose Index and carotid plaque in Japanese population: a cross-sectional study |
| title_sort | association between triglyceride glucose index and carotid plaque in japanese population a cross sectional study |
| url | https://bmjopen.bmj.com/content/13/6/e069663.full |
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