The role of adhesion protein Fibulin7 in development and diseases
Abstract Fibulins are a family of secreted glycoproteins, which play an important role in regulating multiple cellular functions such as adhesion, growth, motility, and survival. Fibulin7 (Fbln7) is expressed in developing odontoblasts, in the giant trophoblast layer of the placenta, in the choroid...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Molecular Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10020-020-00169-z |
| _version_ | 1818553053191602176 |
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| author | Papiya Chakraborty Shiba Prasad Dash Pranita P. Sarangi |
| author_facet | Papiya Chakraborty Shiba Prasad Dash Pranita P. Sarangi |
| author_sort | Papiya Chakraborty |
| collection | DOAJ |
| description | Abstract Fibulins are a family of secreted glycoproteins, which play an important role in regulating multiple cellular functions such as adhesion, growth, motility, and survival. Fibulin7 (Fbln7) is expressed in developing odontoblasts, in the giant trophoblast layer of the placenta, in the choroid of the eyes as well as in the cartilage. Since its discovery, reports from various research groups have improved our understanding about the roles and effects of Fbln7 and Fbln7 derived fragments and peptides under physiological and pathological conditions such as tooth development, angiogenesis, immunoregulation, cancer pathogenesis and very recently as a possible biomarker for glaucoma. This review will highlight the latest developments in our understanding of the functions, the proposed mechanism of actions, and Fbln7’s possible implications in future research and as therapeutics for different diseases. |
| first_indexed | 2024-12-12T09:21:01Z |
| format | Article |
| id | doaj.art-ed7f6db6ad2743fd8f916ca683f4c143 |
| institution | Directory Open Access Journal |
| issn | 1076-1551 1528-3658 |
| language | English |
| last_indexed | 2024-12-12T09:21:01Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj.art-ed7f6db6ad2743fd8f916ca683f4c1432022-12-22T00:29:13ZengBMCMolecular Medicine1076-15511528-36582020-05-012611710.1186/s10020-020-00169-zThe role of adhesion protein Fibulin7 in development and diseasesPapiya Chakraborty0Shiba Prasad Dash1Pranita P. Sarangi2Department of Biotechnology, Indian Institute of Technology RoorkeeDepartment of Biotechnology, Indian Institute of Technology RoorkeeDepartment of Biotechnology, Indian Institute of Technology RoorkeeAbstract Fibulins are a family of secreted glycoproteins, which play an important role in regulating multiple cellular functions such as adhesion, growth, motility, and survival. Fibulin7 (Fbln7) is expressed in developing odontoblasts, in the giant trophoblast layer of the placenta, in the choroid of the eyes as well as in the cartilage. Since its discovery, reports from various research groups have improved our understanding about the roles and effects of Fbln7 and Fbln7 derived fragments and peptides under physiological and pathological conditions such as tooth development, angiogenesis, immunoregulation, cancer pathogenesis and very recently as a possible biomarker for glaucoma. This review will highlight the latest developments in our understanding of the functions, the proposed mechanism of actions, and Fbln7’s possible implications in future research and as therapeutics for different diseases.http://link.springer.com/article/10.1186/s10020-020-00169-zFibulinsFibulin-7Extracellular matrix proteinAdhesion moleculeTherapeutics |
| spellingShingle | Papiya Chakraborty Shiba Prasad Dash Pranita P. Sarangi The role of adhesion protein Fibulin7 in development and diseases Molecular Medicine Fibulins Fibulin-7 Extracellular matrix protein Adhesion molecule Therapeutics |
| title | The role of adhesion protein Fibulin7 in development and diseases |
| title_full | The role of adhesion protein Fibulin7 in development and diseases |
| title_fullStr | The role of adhesion protein Fibulin7 in development and diseases |
| title_full_unstemmed | The role of adhesion protein Fibulin7 in development and diseases |
| title_short | The role of adhesion protein Fibulin7 in development and diseases |
| title_sort | role of adhesion protein fibulin7 in development and diseases |
| topic | Fibulins Fibulin-7 Extracellular matrix protein Adhesion molecule Therapeutics |
| url | http://link.springer.com/article/10.1186/s10020-020-00169-z |
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