Supplementation of Foals with a <i>Saccharomyces cerevisiae</i> Fermentation Product Alters the Early Response to Vaccination
Feed supplements supporting animal welfare and performance are becoming increasingly important. Immunomodulatory effects of such products have been observed in many species. The aim of this study was to analyze whether food supplementation with a <i>Saccharomyces cerevisiae</i> fermentat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/14/6/960 |
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| author | Eva Ronja Terpeluk Jana Schäfer Christa Finkler-Schade Hans-Joachim Schuberth |
| author_facet | Eva Ronja Terpeluk Jana Schäfer Christa Finkler-Schade Hans-Joachim Schuberth |
| author_sort | Eva Ronja Terpeluk |
| collection | DOAJ |
| description | Feed supplements supporting animal welfare and performance are becoming increasingly important. Immunomodulatory effects of such products have been observed in many species. The aim of this study was to analyze whether food supplementation with a <i>Saccharomyces cerevisiae</i> fermentation product (SCFP) affects the occurrence of foal diarrhea in early life, and whether the SCFP feeding has an impact on the immediate response to a parenteral vaccination at the age of 6–9 months. Eleven foals received the SCFP (OLI) and eleven foals were fed a placebo (PLA) for 29 days. Growth, diarrhea, and diarrhea severity were observed until day 30. After weaning, at the age of 6–9 months, foals were vaccinated parenterally against influenza and tetanus. The supplementation had no statistically significant effect on diarrhea duration and severity. On the day of vaccination, PLA and OLI foals did not differ significantly regarding numbers of circulating blood leukocyte subsets. However, the response to vaccination differed significantly between OLI and PLA foals. In OLI foals, the numbers of the major leukocyte fractions (granulocytes, lymphocytes, monocytes, CD4+ T cells, CD8+ T cells, CD21+ B cells, and MHC-II+/CD21− cells) increased significantly 24 h after vaccination but remained unchanged in PLA foals. The observed results suggest that early life supplementation with an SCFP may affect the early immune response to an initial vaccination. |
| first_indexed | 2024-04-24T18:38:18Z |
| format | Article |
| id | doaj.art-ed816eb1df874d8a8a05250fb2c79c83 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-04-24T18:38:18Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-ed816eb1df874d8a8a05250fb2c79c832024-03-27T13:17:57ZengMDPI AGAnimals2076-26152024-03-0114696010.3390/ani14060960Supplementation of Foals with a <i>Saccharomyces cerevisiae</i> Fermentation Product Alters the Early Response to VaccinationEva Ronja Terpeluk0Jana Schäfer1Christa Finkler-Schade2Hans-Joachim Schuberth3Institute for Immunology, University of Veterinary Medicine Foundation, Bünteweg 2, 30559 Hannover, GermanySchäfer Horse Breeding, 38159 Vechelde, GermanySchade & Partner, 27283 Verden, GermanyInstitute for Immunology, University of Veterinary Medicine Foundation, Bünteweg 2, 30559 Hannover, GermanyFeed supplements supporting animal welfare and performance are becoming increasingly important. Immunomodulatory effects of such products have been observed in many species. The aim of this study was to analyze whether food supplementation with a <i>Saccharomyces cerevisiae</i> fermentation product (SCFP) affects the occurrence of foal diarrhea in early life, and whether the SCFP feeding has an impact on the immediate response to a parenteral vaccination at the age of 6–9 months. Eleven foals received the SCFP (OLI) and eleven foals were fed a placebo (PLA) for 29 days. Growth, diarrhea, and diarrhea severity were observed until day 30. After weaning, at the age of 6–9 months, foals were vaccinated parenterally against influenza and tetanus. The supplementation had no statistically significant effect on diarrhea duration and severity. On the day of vaccination, PLA and OLI foals did not differ significantly regarding numbers of circulating blood leukocyte subsets. However, the response to vaccination differed significantly between OLI and PLA foals. In OLI foals, the numbers of the major leukocyte fractions (granulocytes, lymphocytes, monocytes, CD4+ T cells, CD8+ T cells, CD21+ B cells, and MHC-II+/CD21− cells) increased significantly 24 h after vaccination but remained unchanged in PLA foals. The observed results suggest that early life supplementation with an SCFP may affect the early immune response to an initial vaccination.https://www.mdpi.com/2076-2615/14/6/960<i>Saccharomyces cerevisiae</i>SCFPprebioticspostbioticsdiarrheavaccination |
| spellingShingle | Eva Ronja Terpeluk Jana Schäfer Christa Finkler-Schade Hans-Joachim Schuberth Supplementation of Foals with a <i>Saccharomyces cerevisiae</i> Fermentation Product Alters the Early Response to Vaccination Animals <i>Saccharomyces cerevisiae</i> SCFP prebiotics postbiotics diarrhea vaccination |
| title | Supplementation of Foals with a <i>Saccharomyces cerevisiae</i> Fermentation Product Alters the Early Response to Vaccination |
| title_full | Supplementation of Foals with a <i>Saccharomyces cerevisiae</i> Fermentation Product Alters the Early Response to Vaccination |
| title_fullStr | Supplementation of Foals with a <i>Saccharomyces cerevisiae</i> Fermentation Product Alters the Early Response to Vaccination |
| title_full_unstemmed | Supplementation of Foals with a <i>Saccharomyces cerevisiae</i> Fermentation Product Alters the Early Response to Vaccination |
| title_short | Supplementation of Foals with a <i>Saccharomyces cerevisiae</i> Fermentation Product Alters the Early Response to Vaccination |
| title_sort | supplementation of foals with a i saccharomyces cerevisiae i fermentation product alters the early response to vaccination |
| topic | <i>Saccharomyces cerevisiae</i> SCFP prebiotics postbiotics diarrhea vaccination |
| url | https://www.mdpi.com/2076-2615/14/6/960 |
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