Cardiac electrophysiology in mice: a matter of size.
Over the last decade, mouse models have become a popular instrument for studying cardiac arrhythmias. This review assesses in which respects a mouse heart is a miniature human heart, suitable model for studying mechanisms of cardiac arrhythmias in humans and in which respects human and murine hearts...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-09-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00345/full |
| _version_ | 1818984060908732416 |
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| author | Sven eKaese Sander eVerheule |
| author_facet | Sven eKaese Sander eVerheule |
| author_sort | Sven eKaese |
| collection | DOAJ |
| description | Over the last decade, mouse models have become a popular instrument for studying cardiac arrhythmias. This review assesses in which respects a mouse heart is a miniature human heart, suitable model for studying mechanisms of cardiac arrhythmias in humans and in which respects human and murine hearts differ. Section I considers the issue of scaling of mammalian cardiac (electro)physiology to body mass. Then, we summarize differences between mice and humans in cardiac activation (section II) and the currents underlying the action potential in the murine working myocardium (section III). Changes in cardiac electrophysiology in mouse models of heart disease are briefly outlined in sections IV, while section V discusses technical considerations pertaining to recording cardiac electrical activity in mice. Finally, section VI offers general considerations on the influence of cardiac size on the mechanisms of tachy-arrhythmias. |
| first_indexed | 2024-12-20T18:13:00Z |
| format | Article |
| id | doaj.art-ed81ee34999e4533b095cb83a497a1bb |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T18:13:00Z |
| publishDate | 2012-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-ed81ee34999e4533b095cb83a497a1bb2022-12-21T19:30:26ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2012-09-01310.3389/fphys.2012.0034529023Cardiac electrophysiology in mice: a matter of size.Sven eKaese0Sander eVerheule1University Hospital MünsterMaastricht UniversityOver the last decade, mouse models have become a popular instrument for studying cardiac arrhythmias. This review assesses in which respects a mouse heart is a miniature human heart, suitable model for studying mechanisms of cardiac arrhythmias in humans and in which respects human and murine hearts differ. Section I considers the issue of scaling of mammalian cardiac (electro)physiology to body mass. Then, we summarize differences between mice and humans in cardiac activation (section II) and the currents underlying the action potential in the murine working myocardium (section III). Changes in cardiac electrophysiology in mouse models of heart disease are briefly outlined in sections IV, while section V discusses technical considerations pertaining to recording cardiac electrical activity in mice. Finally, section VI offers general considerations on the influence of cardiac size on the mechanisms of tachy-arrhythmias.http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00345/fullAtrial FibrillationVentricular FibrillationMousearrhythmiasconductionScaling |
| spellingShingle | Sven eKaese Sander eVerheule Cardiac electrophysiology in mice: a matter of size. Frontiers in Physiology Atrial Fibrillation Ventricular Fibrillation Mouse arrhythmias conduction Scaling |
| title | Cardiac electrophysiology in mice: a matter of size. |
| title_full | Cardiac electrophysiology in mice: a matter of size. |
| title_fullStr | Cardiac electrophysiology in mice: a matter of size. |
| title_full_unstemmed | Cardiac electrophysiology in mice: a matter of size. |
| title_short | Cardiac electrophysiology in mice: a matter of size. |
| title_sort | cardiac electrophysiology in mice a matter of size |
| topic | Atrial Fibrillation Ventricular Fibrillation Mouse arrhythmias conduction Scaling |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00345/full |
| work_keys_str_mv | AT svenekaese cardiacelectrophysiologyinmiceamatterofsize AT sandereverheule cardiacelectrophysiologyinmiceamatterofsize |