Ros-responsive nanocomposite scaffolds for sustained releasing puerarin to achieve chondroprotection in OA rats

Ros-responsive nanocomposite scaffolds for sustained releasing puerarin to achieve chondroprotection in OA rats

Reactive Oxygen Species (ROS) plays an important role in osteoarthritis (OA) development and progression. Here, a ROS-responsive nanocomposite scaffold called PPE@rGO-Pue was fabricated by electrospinning, wherein PCL served as the backbone, PEGDA-EDT as the ROS responsive motif, and rGO as puerarin...

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Bibliographic Details
Main Authors: Depeng Fang, Zainen Qin, Li Zheng, Pek Yin Michelle Yew, Xianfang Jiang, Dan Kai, Fangming Song, Jinmin Zhao
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Materials & Design
Subjects:
Antioxidative biomaterial
Reactive oxygen species
Drug release
Nanofibers
Osteoarthritis
Cartilage regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127523006299

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http://www.sciencedirect.com/science/article/pii/S0264127523006299

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