Attenuation of a Pathogenic <italic toggle="yes">Mycoplasma</italic> Strain by Modification of the <italic toggle="yes">obg</italic> Gene by Using Synthetic Biology Approaches

Attenuation of a Pathogenic <italic toggle="yes">Mycoplasma</italic> Strain by Modification of the <italic toggle="yes">obg</italic> Gene by Using Synthetic Biology Approaches

ABSTRACT Mycoplasma species are responsible for several economically significant livestock diseases for which there is a need for new and improved vaccines. Most of the existing mycoplasma vaccines are attenuated strains that have been empirically obtained by serial passages or by chemical mutagenes...

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Bibliographic Details
Main Authors: Carole Lartigue, Yanina Valverde Timana, Fabien Labroussaa, Elise Schieck, Anne Liljander, Flavio Sacchini, Horst Posthaus, Brigitte Batailler, Pascal Sirand-Pugnet, Sanjay Vashee, Joerg Jores, Alain Blanchard
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mSphere
Subjects:
GTPase Obg
Mycoplasma
Saccharomyces cerevisiae
attenuated strain
genome engineering
genome transplantation
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00030-19

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