Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics
Exosomes (EXOs) were given attention as an extracellular vesicle (EV) with a pivotal pathophysiological role in the development of certain neurodegenerative disorders (NDD), such as Parkinson’s and Alzheimer’s disease (AD). EXOs have shown the potential to carry pathological and therapeutic cargo; t...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/19/10794 |
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| author | Hagar M. Soliman Ghada A. Ghonaim Shaza M. Gharib Hitesh Chopra Aya K. Farag Mohamed H. Hassanin Abdalrazeq Nagah Mahmoud Emad-Eldin Nevertary E. Hashem Galal Yahya Sherif E. Emam Abdalla E. A. Hassan Mohamed S. Attia |
| author_facet | Hagar M. Soliman Ghada A. Ghonaim Shaza M. Gharib Hitesh Chopra Aya K. Farag Mohamed H. Hassanin Abdalrazeq Nagah Mahmoud Emad-Eldin Nevertary E. Hashem Galal Yahya Sherif E. Emam Abdalla E. A. Hassan Mohamed S. Attia |
| author_sort | Hagar M. Soliman |
| collection | DOAJ |
| description | Exosomes (EXOs) were given attention as an extracellular vesicle (EV) with a pivotal pathophysiological role in the development of certain neurodegenerative disorders (NDD), such as Parkinson’s and Alzheimer’s disease (AD). EXOs have shown the potential to carry pathological and therapeutic cargo; thus, researchers have harnessed EXOs in drug delivery applications. EXOs have shown low immunogenicity as natural drug delivery vehicles, thus ensuring efficient drug delivery without causing significant adverse reactions. Recently, EXOs provided potential drug delivery opportunities in AD and promising future clinical applications with the diagnosis of NDD and were studied for their usefulness in disease detection and prediction prior to the emergence of symptoms. In the future, the microfluidics technique will play an essential role in isolating and detecting EXOs to diagnose AD before the development of advanced symptoms. This review is not reiterative literature but will discuss why EXOs have strong potential in treating AD and how they can be used as a tool to predict and diagnose this disorder. |
| first_indexed | 2024-03-10T06:59:25Z |
| format | Article |
| id | doaj.art-ed83efe8a3044c05ba6da445ef6f3ca0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:59:25Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ed83efe8a3044c05ba6da445ef6f3ca02023-11-22T16:15:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122191079410.3390/ijms221910794Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and TherapeuticsHagar M. Soliman0Ghada A. Ghonaim1Shaza M. Gharib2Hitesh Chopra3Aya K. Farag4Mohamed H. Hassanin5Abdalrazeq Nagah6Mahmoud Emad-Eldin7Nevertary E. Hashem8Galal Yahya9Sherif E. Emam10Abdalla E. A. Hassan11Mohamed S. Attia12Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptChitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Clinical, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptApplied Nucleic Acids Research Center & Chemistry, Faculty of Science, Zagazig 44519, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptExosomes (EXOs) were given attention as an extracellular vesicle (EV) with a pivotal pathophysiological role in the development of certain neurodegenerative disorders (NDD), such as Parkinson’s and Alzheimer’s disease (AD). EXOs have shown the potential to carry pathological and therapeutic cargo; thus, researchers have harnessed EXOs in drug delivery applications. EXOs have shown low immunogenicity as natural drug delivery vehicles, thus ensuring efficient drug delivery without causing significant adverse reactions. Recently, EXOs provided potential drug delivery opportunities in AD and promising future clinical applications with the diagnosis of NDD and were studied for their usefulness in disease detection and prediction prior to the emergence of symptoms. In the future, the microfluidics technique will play an essential role in isolating and detecting EXOs to diagnose AD before the development of advanced symptoms. This review is not reiterative literature but will discuss why EXOs have strong potential in treating AD and how they can be used as a tool to predict and diagnose this disorder.https://www.mdpi.com/1422-0067/22/19/10794exosomesneurodegenerative disordersdrug deliverydiagnosistreatmentcargo |
| spellingShingle | Hagar M. Soliman Ghada A. Ghonaim Shaza M. Gharib Hitesh Chopra Aya K. Farag Mohamed H. Hassanin Abdalrazeq Nagah Mahmoud Emad-Eldin Nevertary E. Hashem Galal Yahya Sherif E. Emam Abdalla E. A. Hassan Mohamed S. Attia Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics International Journal of Molecular Sciences exosomes neurodegenerative disorders drug delivery diagnosis treatment cargo |
| title | Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics |
| title_full | Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics |
| title_fullStr | Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics |
| title_full_unstemmed | Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics |
| title_short | Exosomes in Alzheimer’s Disease: From Being Pathological Players to Potential Diagnostics and Therapeutics |
| title_sort | exosomes in alzheimer s disease from being pathological players to potential diagnostics and therapeutics |
| topic | exosomes neurodegenerative disorders drug delivery diagnosis treatment cargo |
| url | https://www.mdpi.com/1422-0067/22/19/10794 |
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