Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin Invasion
Objectives: To determine the efficacy and toxicity of palliative radiotherapy for locally advanced breast cancer patients with skin invasion. Study Design: Quasi-experimental study. Place and Duration of Study: Radiotherapy Department Combined Military Hospital, Rawalpindi Pakistan, Jan 2019...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-08-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/7443 |
| _version_ | 1827822273665433600 |
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| author | Talha Maqsood Adnan Zeb Zeeshan Ahmed Alvi Sameed Hussain Muhammad Imran Wajid Omer Riaz |
| author_facet | Talha Maqsood Adnan Zeb Zeeshan Ahmed Alvi Sameed Hussain Muhammad Imran Wajid Omer Riaz |
| author_sort | Talha Maqsood |
| collection | DOAJ |
| description |
Objectives: To determine the efficacy and toxicity of palliative radiotherapy for locally advanced breast cancer patients with skin invasion.
Study Design: Quasi-experimental study.
Place and Duration of Study: Radiotherapy Department Combined Military Hospital, Rawalpindi Pakistan, Jan 2019 to Jun 2020.
Methodology: Patients who received palliative radiotherapy for the breast cancer and received radiation of 24 Gray in 3 fractions to the breast/ chest wall were included. Radiation toxicity was assessed using RTOG criteria as the primary outcome of the study. Radiotherapy efficacy in controlling bleeding/discharge and improving pain and odour scores were the secondary outcomes.
Results: Twelve (80%) patients reported improvement in pain, 13/18(72.2) patients reported improvement in bleeding and 24/25 (96%) patients a decrease in pain level (p-value < 0.001). 11/25(44%) developed Grade-2 skin toxicity, and 8/25 (32%) developed Grade-3 skin toxicity. No patient experienced Grade-4 skin toxicity.
Conclusion: Our study has shown that hypofractionated radiotherapy is effective and safe for palliation of patients with locally advanced breast cancer and skin invasion.
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| first_indexed | 2024-03-12T01:55:44Z |
| format | Article |
| id | doaj.art-ed8468d9ca8f4b93a13ef73440f7d9da |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-03-12T01:55:44Z |
| publishDate | 2023-08-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-ed8468d9ca8f4b93a13ef73440f7d9da2023-09-08T05:59:58ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-08-0173410.51253/pafmj.v73i4.7443Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin InvasionTalha Maqsood0Adnan Zeb1Zeeshan Ahmed Alvi2Sameed Hussain3Muhammad Imran Wajid4Omer Riaz5Department of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Oncology, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan Objectives: To determine the efficacy and toxicity of palliative radiotherapy for locally advanced breast cancer patients with skin invasion. Study Design: Quasi-experimental study. Place and Duration of Study: Radiotherapy Department Combined Military Hospital, Rawalpindi Pakistan, Jan 2019 to Jun 2020. Methodology: Patients who received palliative radiotherapy for the breast cancer and received radiation of 24 Gray in 3 fractions to the breast/ chest wall were included. Radiation toxicity was assessed using RTOG criteria as the primary outcome of the study. Radiotherapy efficacy in controlling bleeding/discharge and improving pain and odour scores were the secondary outcomes. Results: Twelve (80%) patients reported improvement in pain, 13/18(72.2) patients reported improvement in bleeding and 24/25 (96%) patients a decrease in pain level (p-value < 0.001). 11/25(44%) developed Grade-2 skin toxicity, and 8/25 (32%) developed Grade-3 skin toxicity. No patient experienced Grade-4 skin toxicity. Conclusion: Our study has shown that hypofractionated radiotherapy is effective and safe for palliation of patients with locally advanced breast cancer and skin invasion. https://www.pafmj.org/index.php/PAFMJ/article/view/7443Breast cancerHypofractionated hypofractionated palliative radiotherapyPalliative therapy |
| spellingShingle | Talha Maqsood Adnan Zeb Zeeshan Ahmed Alvi Sameed Hussain Muhammad Imran Wajid Omer Riaz Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin Invasion Pakistan Armed Forces Medical Journal Breast cancer Hypofractionated hypofractionated palliative radiotherapy Palliative therapy |
| title | Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin Invasion |
| title_full | Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin Invasion |
| title_fullStr | Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin Invasion |
| title_full_unstemmed | Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin Invasion |
| title_short | Efficacy and Toxicity of Hypofractionated Palliative Radiotherapy for Breast Cancer Patients with Skin Invasion |
| title_sort | efficacy and toxicity of hypofractionated palliative radiotherapy for breast cancer patients with skin invasion |
| topic | Breast cancer Hypofractionated hypofractionated palliative radiotherapy Palliative therapy |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/7443 |
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