Cardiac Sarcoidosis: When and How to Treat Inflammation
Sarcoidosis is a complex, multisystem inflammatory disease with a heterogeneous clinical spectrum. Approximately 25% of patients with systemic sarcoidosis will have cardiac involvement that portends a poorer outcome. The diagnosis, particularly of isolated cardiac sarcoidosis, can be challenging. A...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2021-11-01
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| Series: | Cardiac Failure Review |
| Online Access: | https://www.cfrjournal.com/articleindex/cfr.2021.16 |
| _version_ | 1797200086139142144 |
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| author | Gerard T Giblin Laura Murphy Garrick C Stewart Akshay S Desai Marcelo F Di Carli Ron Blankstein Michael M Givertz Usha B Tedrow William H Sauer Gary M Hunninghake Paul F Dellaripa Sanjay Divakaran Neal K Lakdawala |
| author_facet | Gerard T Giblin Laura Murphy Garrick C Stewart Akshay S Desai Marcelo F Di Carli Ron Blankstein Michael M Givertz Usha B Tedrow William H Sauer Gary M Hunninghake Paul F Dellaripa Sanjay Divakaran Neal K Lakdawala |
| author_sort | Gerard T Giblin |
| collection | DOAJ |
| description | Sarcoidosis is a complex, multisystem inflammatory disease with a heterogeneous clinical spectrum. Approximately 25% of patients with systemic sarcoidosis will have cardiac involvement that portends a poorer outcome. The diagnosis, particularly of isolated cardiac sarcoidosis, can be challenging. A paucity of randomised data exist on who, when and how to treat myocardial inflammation in cardiac sarcoidosis. Despite this, corticosteroids continue to be the mainstay of therapy for the inflammatory phase, with an evolving role for steroid-sparing and biological agents. This review explores the immunopathogenesis of inflammation in sarcoidosis, current evidence-based treatment indications and commonly used immunosuppression agents. It explores a multidisciplinary treatment and monitoring approach to myocardial inflammation and outlines current gaps in our understanding of this condition, emerging research and future directions in this field. |
| first_indexed | 2024-03-07T17:41:30Z |
| format | Article |
| id | doaj.art-ed85c46b84b54899967bf07123503384 |
| institution | Directory Open Access Journal |
| issn | 2057-7540 2057-7559 |
| language | English |
| last_indexed | 2024-04-24T07:26:03Z |
| publishDate | 2021-11-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Cardiac Failure Review |
| spelling | doaj.art-ed85c46b84b54899967bf071235033842024-04-20T16:02:29ZengRadcliffe Medical MediaCardiac Failure Review2057-75402057-75592021-11-01710.15420/cfr.2021.16Cardiac Sarcoidosis: When and How to Treat InflammationGerard T Giblin0Laura Murphy1Garrick C Stewart2Akshay S Desai3Marcelo F Di Carli4Ron Blankstein5Michael M Givertz6Usha B Tedrow7William H Sauer8Gary M Hunninghake9Paul F Dellaripa10Sanjay Divakaran11Neal K Lakdawala12Center for Advanced Heart Disease, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCardiovascular Imaging Program and Departments of Medicine and Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCenter for Advanced Heart Disease, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCenter for Advanced Heart Disease, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCardiovascular Imaging Program and Departments of Medicine and Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCardiovascular Imaging Program and Departments of Medicine and Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCenter for Advanced Heart Disease, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCardiac Arrhythmia Service, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCardiac Arrhythmia Service, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USInterstitial Lung Disease Program, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USInterstitial Lung Disease Program, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCenter for Advanced Heart Disease, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USCenter for Advanced Heart Disease, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USSarcoidosis is a complex, multisystem inflammatory disease with a heterogeneous clinical spectrum. Approximately 25% of patients with systemic sarcoidosis will have cardiac involvement that portends a poorer outcome. The diagnosis, particularly of isolated cardiac sarcoidosis, can be challenging. A paucity of randomised data exist on who, when and how to treat myocardial inflammation in cardiac sarcoidosis. Despite this, corticosteroids continue to be the mainstay of therapy for the inflammatory phase, with an evolving role for steroid-sparing and biological agents. This review explores the immunopathogenesis of inflammation in sarcoidosis, current evidence-based treatment indications and commonly used immunosuppression agents. It explores a multidisciplinary treatment and monitoring approach to myocardial inflammation and outlines current gaps in our understanding of this condition, emerging research and future directions in this field.https://www.cfrjournal.com/articleindex/cfr.2021.16 |
| spellingShingle | Gerard T Giblin Laura Murphy Garrick C Stewart Akshay S Desai Marcelo F Di Carli Ron Blankstein Michael M Givertz Usha B Tedrow William H Sauer Gary M Hunninghake Paul F Dellaripa Sanjay Divakaran Neal K Lakdawala Cardiac Sarcoidosis: When and How to Treat Inflammation Cardiac Failure Review |
| title | Cardiac Sarcoidosis: When and How to Treat Inflammation |
| title_full | Cardiac Sarcoidosis: When and How to Treat Inflammation |
| title_fullStr | Cardiac Sarcoidosis: When and How to Treat Inflammation |
| title_full_unstemmed | Cardiac Sarcoidosis: When and How to Treat Inflammation |
| title_short | Cardiac Sarcoidosis: When and How to Treat Inflammation |
| title_sort | cardiac sarcoidosis when and how to treat inflammation |
| url | https://www.cfrjournal.com/articleindex/cfr.2021.16 |
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