Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer Treatment
Many cancers have evolved various mechanisms to evade immunological surveillance, such as the inhibitory immune checkpoint of the CD47-SIRPα signaling pathway. By targeting this signaling pathway, researchers have developed diverse nanovehicles with different loaded drugs and modifications in antica...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.887463/full |
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| author | Haiqin Liao Haiqin Liao Chengcheng Niu Chengcheng Niu |
| author_facet | Haiqin Liao Haiqin Liao Chengcheng Niu Chengcheng Niu |
| author_sort | Haiqin Liao |
| collection | DOAJ |
| description | Many cancers have evolved various mechanisms to evade immunological surveillance, such as the inhibitory immune checkpoint of the CD47-SIRPα signaling pathway. By targeting this signaling pathway, researchers have developed diverse nanovehicles with different loaded drugs and modifications in anticancer treatment. In this review, we present a brief overview of CD47-SIRPα interaction and nanomedicine. Then, we delve into recent applications of the CD47-SIRPα interaction as a target for nanomedicine-based antitumor treatment and its combination with other targeting pathway drugs and/or therapeutic approaches. |
| first_indexed | 2024-12-10T09:54:40Z |
| format | Article |
| id | doaj.art-ed87b5ea1aaa4d72a778d088fd6634e6 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-10T09:54:40Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-ed87b5ea1aaa4d72a778d088fd6634e62022-12-22T01:53:32ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-04-011010.3389/fbioe.2022.887463887463Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer TreatmentHaiqin Liao0Haiqin Liao1Chengcheng Niu2Chengcheng Niu3Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, ChinaResearch Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, ChinaMany cancers have evolved various mechanisms to evade immunological surveillance, such as the inhibitory immune checkpoint of the CD47-SIRPα signaling pathway. By targeting this signaling pathway, researchers have developed diverse nanovehicles with different loaded drugs and modifications in anticancer treatment. In this review, we present a brief overview of CD47-SIRPα interaction and nanomedicine. Then, we delve into recent applications of the CD47-SIRPα interaction as a target for nanomedicine-based antitumor treatment and its combination with other targeting pathway drugs and/or therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fbioe.2022.887463/fullcd47SIRPαtumorimmunotherapynanomedicine |
| spellingShingle | Haiqin Liao Haiqin Liao Chengcheng Niu Chengcheng Niu Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer Treatment Frontiers in Bioengineering and Biotechnology cd47 SIRPα tumor immunotherapy nanomedicine |
| title | Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer Treatment |
| title_full | Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer Treatment |
| title_fullStr | Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer Treatment |
| title_full_unstemmed | Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer Treatment |
| title_short | Role of CD47-SIRPα Checkpoint in Nanomedicine-Based Anti-Cancer Treatment |
| title_sort | role of cd47 sirpα checkpoint in nanomedicine based anti cancer treatment |
| topic | cd47 SIRPα tumor immunotherapy nanomedicine |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.887463/full |
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