Hematopoietic Cell Transplantation for MHC Class II Deficiency

Hematopoietic Cell Transplantation for MHC Class II Deficiency

Major histocompatibility complex (MHC) class II deficiency is a rare and fatal primary combined immunodeficiency. It affects both marrow-derived cells and thymic epithelium, leading to impaired antigen presentation by antigen presenting cells and delayed and incomplete maturation of CD4+ lymphocyte...

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Bibliographic Details
Main Authors: Su Han Lum, Benedicte Neven, Mary A. Slatter, Andrew R. Gennery
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pediatrics
Subjects:
MHC class II deficiency
children
hematopoietic cell transplantation
transplant strategy
survival
Online Access:https://www.frontiersin.org/article/10.3389/fped.2019.00516/full

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