Structural Mechanisms of Store-Operated and Mitochondrial Calcium Regulation: Initiation Points for Drug Discovery

Structural Mechanisms of Store-Operated and Mitochondrial Calcium Regulation: Initiation Points for Drug Discovery

Calcium (Ca<sup>2+</sup>) is a universal signaling ion that is essential for the life and death processes of all eukaryotes. In humans, numerous cell stimulation pathways lead to the mobilization of sarco/endoplasmic reticulum (S/ER) stored Ca<sup>2+</sup>, resulting in the p...

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Bibliographic Details
Main Authors:	Megan Noble, Qi-Tong Lin, Christian Sirko, Jacob A. Houpt, Matthew J. Novello, Peter B. Stathopulos
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Series:	International Journal of Molecular Sciences
Subjects:	calcium signaling store-operated calcium entry stromal interaction molecule Orai1 mitochondrial calcium uniporter leucine-zipper EF-hand containing transmembrane protein-1
Online Access:	https://www.mdpi.com/1422-0067/21/10/3642

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