UPLC-LTQ-Orbitrap-Based Cell Metabolomics and Network Pharmacology Analysis to Reveal the Potential Antiarthritic Effects of Pristimerin: In Vitro, In Silico and In Vivo Study

UPLC-LTQ-Orbitrap-Based Cell Metabolomics and Network Pharmacology Analysis to Reveal the Potential Antiarthritic Effects of Pristimerin: In Vitro, In Silico and In Vivo Study

Rheumatoid arthritis (RA) is characterized by systemic inflammation and synovial hyperplasia. Pristimerin, a natural triterpenoid isolated from plants belonging to the Celastraceae and Hippocrateaceae families, has been reported to exhibit anti-inflammation and anti-proliferation activities. Our stu...

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Bibliographic Details
Main Authors: Mengying Lv, Qiaoling Liang, Zhaoyong Luo, Bo Han, Tengyang Ni, Yang Wang, Li Tao, Weiting Lyu, Jie Xiang, Yanqing Liu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Metabolites
Subjects:
pristimerin
rheumatoid arthritis
cell metabolomics
network pharmacology analysis
MH7A
adjuvant-induced arthritis
Online Access:https://www.mdpi.com/2218-1989/12/9/839

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