| Summary: | <i>Salmonella</i> is important as both a cause of clinical disease in swine and as a source of food-borne transmission of disease to humans. <i>Lactobacillus</i> and <i>Bacillus</i> are often used as antibiotic substitutes to prevent <i>Salmonella</i> infection. In this study, we evaluated the effects of a select mixture of <i>Lactobacillus johnsonii</i> L531, <i>Bacillus licheniformis</i> BL1721 and <i>Bacillus subtilis</i> BS1715 (LBB-mix) in prevention of <i>Salmonella</i> <i>enterica</i> serovar Infantis infection in a pig model. LBB-mix was orally administered to newly weaned piglets for seven days before <i>S</i>. Infantis challenge. LBB-mix pretreatment ameliorated <i>S</i>. Infantis-induced fever, leukocytosis, growth performance loss, and ileal inflammation. Pre-administration of LBB-mix reduced the number of <i>Salmonella</i> in the feces but increased the number of goblet cells in the ileum. <i>S</i>. Infantis infection resulted in an increase in cell death in the ileum, this increase was attenuated by LBB-mix consumption. Claudin 1 and cleaved caspase-1 expression was decreased in the ileum of pigs challenged with <i>S</i>. Infantis, but not in pigs pretreated with LBB-mix. In conclusion, our data indicate that a select LBB-mix has positive effects on controlling <i>S</i>. Infantis infection via alleviating inflammation and maintaining the intestinal mucosal barrier integrity in pigs.
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