Cancer cell invasion is enhanced by applied mechanical stimulation.
Metastatic cells migrate from the site of the primary tumor, through the stroma, into the blood and lymphatic vessels, finally colonizing various other tissues to form secondary tumors. Numerous studies have been done to identify the stimuli that drive the metastatic cascade. This has led to the ide...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3040771?pdf=render |
| _version_ | 1818540815923806208 |
|---|---|
| author | Shalini Menon Karen A Beningo |
| author_facet | Shalini Menon Karen A Beningo |
| author_sort | Shalini Menon |
| collection | DOAJ |
| description | Metastatic cells migrate from the site of the primary tumor, through the stroma, into the blood and lymphatic vessels, finally colonizing various other tissues to form secondary tumors. Numerous studies have been done to identify the stimuli that drive the metastatic cascade. This has led to the identification of multiple biochemical signals that promote metastasis. However, information on the role of mechanical factors in cancer metastasis has been limited to the affect of compliance. Interestingly, the tumor microenvironment is rich in many cell types including highly contractile cells that are responsible for extensive remodeling and production of the dense extracellular matrix surrounding the cancerous tissue. We hypothesize that the mechanical forces produced by remodeling activities of cells in the tumor microenvironment contribute to the invasion efficiency of metastatic cells. We have discovered a significant difference in the extent of invasion in mechanically stimulated verses non-stimulated cell culture environments. Furthermore, this mechanically enhanced invasion is dependent upon substrate protein composition, and influenced by topography. Finally, we have found that the protein cofilin is needed to sense the mechanical stimuli that enhances invasion. We conclude that other types of mechanical signals in the tumor microenvironment, besides the rigidity, can enhance the invasive abilities of cancer cells in vitro. We further propose that in vivo, non-cancerous cells located within the tumor micro-environment may be capable of providing the necessary mechanical stimulus during the remodeling of the extracellular matrix surrounding the tumor. |
| first_indexed | 2024-12-11T22:00:21Z |
| format | Article |
| id | doaj.art-ed8b4a733ee44433b199d766e07cbcf0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T22:00:21Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ed8b4a733ee44433b199d766e07cbcf02022-12-22T00:49:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0162e1727710.1371/journal.pone.0017277Cancer cell invasion is enhanced by applied mechanical stimulation.Shalini MenonKaren A BeningoMetastatic cells migrate from the site of the primary tumor, through the stroma, into the blood and lymphatic vessels, finally colonizing various other tissues to form secondary tumors. Numerous studies have been done to identify the stimuli that drive the metastatic cascade. This has led to the identification of multiple biochemical signals that promote metastasis. However, information on the role of mechanical factors in cancer metastasis has been limited to the affect of compliance. Interestingly, the tumor microenvironment is rich in many cell types including highly contractile cells that are responsible for extensive remodeling and production of the dense extracellular matrix surrounding the cancerous tissue. We hypothesize that the mechanical forces produced by remodeling activities of cells in the tumor microenvironment contribute to the invasion efficiency of metastatic cells. We have discovered a significant difference in the extent of invasion in mechanically stimulated verses non-stimulated cell culture environments. Furthermore, this mechanically enhanced invasion is dependent upon substrate protein composition, and influenced by topography. Finally, we have found that the protein cofilin is needed to sense the mechanical stimuli that enhances invasion. We conclude that other types of mechanical signals in the tumor microenvironment, besides the rigidity, can enhance the invasive abilities of cancer cells in vitro. We further propose that in vivo, non-cancerous cells located within the tumor micro-environment may be capable of providing the necessary mechanical stimulus during the remodeling of the extracellular matrix surrounding the tumor.http://europepmc.org/articles/PMC3040771?pdf=render |
| spellingShingle | Shalini Menon Karen A Beningo Cancer cell invasion is enhanced by applied mechanical stimulation. PLoS ONE |
| title | Cancer cell invasion is enhanced by applied mechanical stimulation. |
| title_full | Cancer cell invasion is enhanced by applied mechanical stimulation. |
| title_fullStr | Cancer cell invasion is enhanced by applied mechanical stimulation. |
| title_full_unstemmed | Cancer cell invasion is enhanced by applied mechanical stimulation. |
| title_short | Cancer cell invasion is enhanced by applied mechanical stimulation. |
| title_sort | cancer cell invasion is enhanced by applied mechanical stimulation |
| url | http://europepmc.org/articles/PMC3040771?pdf=render |
| work_keys_str_mv | AT shalinimenon cancercellinvasionisenhancedbyappliedmechanicalstimulation AT karenabeningo cancercellinvasionisenhancedbyappliedmechanicalstimulation |