Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction
Courtney A Henry, Ronald A Lyon, Hua Ling Department of Pharmacy Practice, School of Pharmacy, Hampton University, Hampton, VA, USA Abstract: Multiple categories of medications have been developed to manage lipid profiles and reduce the risk of cardiovascular events in patients with heart disease....
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-04-01
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| Series: | Vascular Health and Risk Management |
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| Online Access: | https://www.dovepress.com/clinical-efficacy-and-safety-of-evolocumab-for-low-density-lipoprotein-peer-reviewed-article-VHRM |
| _version_ | 1819152747137597440 |
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| author | Henry CA Lyon RA Ling H |
| author_facet | Henry CA Lyon RA Ling H |
| author_sort | Henry CA |
| collection | DOAJ |
| description | Courtney A Henry, Ronald A Lyon, Hua Ling Department of Pharmacy Practice, School of Pharmacy, Hampton University, Hampton, VA, USA Abstract: Multiple categories of medications have been developed to manage lipid profiles and reduce the risk of cardiovascular events in patients with heart disease. However, currently marketed medications have not solved the problems associated with preventing and treating cardiovascular diseases completely. A substantial population of patients cannot take advantage of statin therapy due to statin intolerance, heart failure, or kidney hemodialysis, suggesting a need for additional effective agents to reduce low-density lipoprotein cholesterol (LDL-C) levels. Proprotein convertase subtilisin/kexin type 9 (PCSK9) was discovered in 2003 and subsequently emerged as a novel target for LDL-C-lowering therapy. Evolocumab is a fully human monoclonal immunoglobulin G2 (IgG2) directed against human PCSK9. By inactivating PCSK9, evolocumab upregulates LDL receptors causing increased catabolism of LDL-C and the consequent reduction of LDL-C levels in blood. Overall, evolocumab has had notable efficacy, with LDL-C reduction ranging from 53% to 75% in monotherapy and combination therapies, and is associated with minor adverse effects. However, studies regarding the ability of evolocumab to reduce mortality as well as long-term safety concerns are limited. The fact that the drug was introduced at a cost much higher than the existing medications and shows a low incremental mortality benefit suggests that many payers will consider evolocumab to have an unfavorable cost–benefit ratio. Keywords: PCSK9, hyperlipidemia, evolocumab, LDL-C, familial hypercholesterolemia |
| first_indexed | 2024-12-22T14:54:12Z |
| format | Article |
| id | doaj.art-ed8ed670b0ec4d0b8f936aa02f4d9a23 |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-22T14:54:12Z |
| publishDate | 2016-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-ed8ed670b0ec4d0b8f936aa02f4d9a232022-12-21T18:22:15ZengDove Medical PressVascular Health and Risk Management1178-20482016-04-012016Issue 116316926533Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reductionHenry CALyon RALing HCourtney A Henry, Ronald A Lyon, Hua Ling Department of Pharmacy Practice, School of Pharmacy, Hampton University, Hampton, VA, USA Abstract: Multiple categories of medications have been developed to manage lipid profiles and reduce the risk of cardiovascular events in patients with heart disease. However, currently marketed medications have not solved the problems associated with preventing and treating cardiovascular diseases completely. A substantial population of patients cannot take advantage of statin therapy due to statin intolerance, heart failure, or kidney hemodialysis, suggesting a need for additional effective agents to reduce low-density lipoprotein cholesterol (LDL-C) levels. Proprotein convertase subtilisin/kexin type 9 (PCSK9) was discovered in 2003 and subsequently emerged as a novel target for LDL-C-lowering therapy. Evolocumab is a fully human monoclonal immunoglobulin G2 (IgG2) directed against human PCSK9. By inactivating PCSK9, evolocumab upregulates LDL receptors causing increased catabolism of LDL-C and the consequent reduction of LDL-C levels in blood. Overall, evolocumab has had notable efficacy, with LDL-C reduction ranging from 53% to 75% in monotherapy and combination therapies, and is associated with minor adverse effects. However, studies regarding the ability of evolocumab to reduce mortality as well as long-term safety concerns are limited. The fact that the drug was introduced at a cost much higher than the existing medications and shows a low incremental mortality benefit suggests that many payers will consider evolocumab to have an unfavorable cost–benefit ratio. Keywords: PCSK9, hyperlipidemia, evolocumab, LDL-C, familial hypercholesterolemiahttps://www.dovepress.com/clinical-efficacy-and-safety-of-evolocumab-for-low-density-lipoprotein-peer-reviewed-article-VHRMPCSK9hyperlipidemiaevolocumabLDL-Cfamilial hypercholesterolemia |
| spellingShingle | Henry CA Lyon RA Ling H Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction Vascular Health and Risk Management PCSK9 hyperlipidemia evolocumab LDL-C familial hypercholesterolemia |
| title | Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction |
| title_full | Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction |
| title_fullStr | Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction |
| title_full_unstemmed | Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction |
| title_short | Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction |
| title_sort | clinical efficacy and safety of evolocumab for low density lipoprotein cholesterol reduction |
| topic | PCSK9 hyperlipidemia evolocumab LDL-C familial hypercholesterolemia |
| url | https://www.dovepress.com/clinical-efficacy-and-safety-of-evolocumab-for-low-density-lipoprotein-peer-reviewed-article-VHRM |
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