Association between occupational lead exposure and plasma levels of selected oxidative stress related parameters in Jordanian automobile workers
Objectives To study any possible correlation between blood lead levels and some oxidative stress parameters of selected groups of lead-exposed automobile occupational Jordanian workers. Material and Methods Blood lead levels were determined for a total of 90 male automobile workers aged within the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nofer Institute of Occupational Medicine
2018-07-01
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| Series: | International Journal of Occupational Medicine and Environmental Health |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/ijomeh/ASSOCIATION-BETWEEN-OCCUPATIONAL-LEAD-r-nEXPOSURE-AND-PLASMA-LEVELS-OF-SELECTED-r,78310,0,2.html |
| Summary: | Objectives
To study any possible correlation between blood lead levels and some oxidative stress parameters of selected
groups of lead-exposed automobile occupational Jordanian workers.
Material and Methods
Blood lead levels were determined
for a total of 90 male automobile workers aged within the range of 25–45 years old along with the group of 20 agematched
healthy males control. To get an idea about the antioxidant status of controls and lead-exposed workers, and to
estimate the oxidative stress caused by exposure to lead, we measured the hydrogen peroxide (H 2 O 2 ) concentration, superoxide
dismutase (SOD) activity, lipid peroxidation as malondialdehyde (MDA) and total antioxidant capacity of controls
and workers.
Results
The study showed that lead levels in the case of workers were approximately 4–5 times as high as in controls 14.5–21 μg×dl –1 vs. 4.3 μg×dl –1 , respectively. There was a significant decrease (16–25%) in the level of plasma reduced glutathione and 21–33% decrease in total antioxidant capacity (TAOC) in all worker groups, as compared to
controls. The results showed that the concentration of malondialdehyde (MDA) in plasma was higher (120–333%) in the
case of workers than controls being the highest in automobile electronics and the lowest – in mechanics. Furthermore,
there was 149–221% increase in hydrogen peroxide (H 2 O 2 ) concentration, and 26–38% increase in SOD activity in the case
of workers compared to the control group.
Conclusions
There is a strong evidence for the associations between occupational
lead exposure and various markers of oxidative stress in Jordanian automobile occupational workers. Thus, there
is an urgent need to raise awareness and to initiate suitable protection guidelines for workers. Int J Occup Med Environ
Health 2018;31(4):517–525 |
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| ISSN: | 1232-1087 1896-494X |