FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies
Drug therapy, including chemotherapy, targeted therapy, immunotherapy, and endocrine therapy, stands as the foremost therapeutic approach for contemporary human malignancies. However, increasing drug resistance during antineoplastic therapy has become a substantial barrier to favorable outcomes in c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1278056/full |
| _version_ | 1797628952951390208 |
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| author | Wanqing Wang Kaipeng Jiang Xue Liu Ju Li Wenshuo Zhou Chang Wang Jiuwei Cui Tingting Liang |
| author_facet | Wanqing Wang Kaipeng Jiang Xue Liu Ju Li Wenshuo Zhou Chang Wang Jiuwei Cui Tingting Liang |
| author_sort | Wanqing Wang |
| collection | DOAJ |
| description | Drug therapy, including chemotherapy, targeted therapy, immunotherapy, and endocrine therapy, stands as the foremost therapeutic approach for contemporary human malignancies. However, increasing drug resistance during antineoplastic therapy has become a substantial barrier to favorable outcomes in cancer patients. To enhance the effectiveness of different cancer therapies, an in-depth understanding of the unique mechanisms underlying tumor drug resistance and the subsequent surmounting of antitumor drug resistance is required. Recently, F-box and WD Repeat Domain-containing-7 (FBXW7), a recognized tumor suppressor, has been found to be highly associated with tumor therapy resistance. This review provides a comprehensive summary of the underlying mechanisms through which FBXW7 facilitates the development of drug resistance in cancer. Additionally, this review elucidates the role of FBXW7 in therapeutic resistance of various types of human tumors. The strategies and challenges implicated in overcoming tumor therapy resistance by targeting FBXW7 are also discussed. |
| first_indexed | 2024-03-11T10:47:35Z |
| format | Article |
| id | doaj.art-ed91a9ac979a405cb35b1cd0217651a2 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-11T10:47:35Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ed91a9ac979a405cb35b1cd0217651a22023-11-14T03:43:57ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.12780561278056FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategiesWanqing WangKaipeng JiangXue LiuJu LiWenshuo ZhouChang WangJiuwei CuiTingting LiangDrug therapy, including chemotherapy, targeted therapy, immunotherapy, and endocrine therapy, stands as the foremost therapeutic approach for contemporary human malignancies. However, increasing drug resistance during antineoplastic therapy has become a substantial barrier to favorable outcomes in cancer patients. To enhance the effectiveness of different cancer therapies, an in-depth understanding of the unique mechanisms underlying tumor drug resistance and the subsequent surmounting of antitumor drug resistance is required. Recently, F-box and WD Repeat Domain-containing-7 (FBXW7), a recognized tumor suppressor, has been found to be highly associated with tumor therapy resistance. This review provides a comprehensive summary of the underlying mechanisms through which FBXW7 facilitates the development of drug resistance in cancer. Additionally, this review elucidates the role of FBXW7 in therapeutic resistance of various types of human tumors. The strategies and challenges implicated in overcoming tumor therapy resistance by targeting FBXW7 are also discussed.https://www.frontiersin.org/articles/10.3389/fphar.2023.1278056/fullFbxw7human tumorsdrug resistancetargeted therapyubiquitin-proteasome system (UPS) |
| spellingShingle | Wanqing Wang Kaipeng Jiang Xue Liu Ju Li Wenshuo Zhou Chang Wang Jiuwei Cui Tingting Liang FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies Frontiers in Pharmacology Fbxw7 human tumors drug resistance targeted therapy ubiquitin-proteasome system (UPS) |
| title | FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies |
| title_full | FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies |
| title_fullStr | FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies |
| title_full_unstemmed | FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies |
| title_short | FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies |
| title_sort | fbxw7 and human tumors mechanisms of drug resistance and potential therapeutic strategies |
| topic | Fbxw7 human tumors drug resistance targeted therapy ubiquitin-proteasome system (UPS) |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1278056/full |
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