Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles
Recently, there has been increasing interest in developing biocompatible inhalable nanoparticle formulations, as they have enormous potential for treating and diagnosing lung disease. In this respect, here, we have studied superparamagnetic iron-doped calcium phosphate (in the form of hydroxyapatite...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/4/189 |
| _version_ | 1797604911222882304 |
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| author | Eride Quarta Michele Chiappi Alessio Adamiano Anna Tampieri Weijie Wang Teresa D. Tetley Francesca Buttini Fabio Sonvico Daniele Catalucci Paolo Colombo Michele Iafisco Lorenzo Degli Esposti |
| author_facet | Eride Quarta Michele Chiappi Alessio Adamiano Anna Tampieri Weijie Wang Teresa D. Tetley Francesca Buttini Fabio Sonvico Daniele Catalucci Paolo Colombo Michele Iafisco Lorenzo Degli Esposti |
| author_sort | Eride Quarta |
| collection | DOAJ |
| description | Recently, there has been increasing interest in developing biocompatible inhalable nanoparticle formulations, as they have enormous potential for treating and diagnosing lung disease. In this respect, here, we have studied superparamagnetic iron-doped calcium phosphate (in the form of hydroxyapatite) nanoparticles (FeCaP NPs) which were previously proved to be excellent materials for magnetic resonance imaging, drug delivery and hyperthermia-related applications. We have established that FeCaP NPs are not cytotoxic towards human lung alveolar epithelial type 1 (AT1) cells even at high doses, thus proving their safety for inhalation administration. Then, D-mannitol spray-dried microparticles embedding FeCaP NPs have been formulated, obtaining respirable dry powders. These microparticles were designed to achieve the best aerodynamic particle size distribution which is a critical condition for successful inhalation and deposition. The nanoparticle-in-microparticle approach resulted in the protection of FeCaP NPs, allowing their release upon microparticle dissolution, with dimensions and surface charge close to the original values. This work demonstrates the use of spray drying to provide an inhalable dry powder platform for the lung delivery of safe FeCaP NPs for magnetically driven applications. |
| first_indexed | 2024-03-11T04:53:28Z |
| format | Article |
| id | doaj.art-ed94a38bf55c44c8b0a9a87dcacd762a |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T04:53:28Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-ed94a38bf55c44c8b0a9a87dcacd762a2023-11-17T19:52:58ZengMDPI AGJournal of Functional Biomaterials2079-49832023-03-0114418910.3390/jfb14040189Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite NanoparticlesEride Quarta0Michele Chiappi1Alessio Adamiano2Anna Tampieri3Weijie Wang4Teresa D. Tetley5Francesca Buttini6Fabio Sonvico7Daniele Catalucci8Paolo Colombo9Michele Iafisco10Lorenzo Degli Esposti11Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, ItalyNational Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 0AZ, UKInstitute of Science, Technology and Sustainability for Ceramic Materials (ISSMC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, ItalyInstitute of Science, Technology and Sustainability for Ceramic Materials (ISSMC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, ItalyNational Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 0AZ, UKNational Heart and Lung Institute, Faculty of Medicine, Imperial College London, London SW7 0AZ, UKDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, ItalyDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, ItalyInstitute of Genetic and Biomedical Research (IRGB), National Research Council (CNR), UOS Milan and IRCCS Humanitas Research Hospital, 20089 Rozzano, ItalyPlumeStars srl, Parco Area Delle Scienze, 27/A, 43125 Parma, ItalyInstitute of Science, Technology and Sustainability for Ceramic Materials (ISSMC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, ItalyInstitute of Science, Technology and Sustainability for Ceramic Materials (ISSMC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, ItalyRecently, there has been increasing interest in developing biocompatible inhalable nanoparticle formulations, as they have enormous potential for treating and diagnosing lung disease. In this respect, here, we have studied superparamagnetic iron-doped calcium phosphate (in the form of hydroxyapatite) nanoparticles (FeCaP NPs) which were previously proved to be excellent materials for magnetic resonance imaging, drug delivery and hyperthermia-related applications. We have established that FeCaP NPs are not cytotoxic towards human lung alveolar epithelial type 1 (AT1) cells even at high doses, thus proving their safety for inhalation administration. Then, D-mannitol spray-dried microparticles embedding FeCaP NPs have been formulated, obtaining respirable dry powders. These microparticles were designed to achieve the best aerodynamic particle size distribution which is a critical condition for successful inhalation and deposition. The nanoparticle-in-microparticle approach resulted in the protection of FeCaP NPs, allowing their release upon microparticle dissolution, with dimensions and surface charge close to the original values. This work demonstrates the use of spray drying to provide an inhalable dry powder platform for the lung delivery of safe FeCaP NPs for magnetically driven applications.https://www.mdpi.com/2079-4983/14/4/189hydroxyapatitesuperparamagnetic nanoparticlesnanomedicinemicroparticles embedding nanoparticlesTrojan microparticlespulmonary disease |
| spellingShingle | Eride Quarta Michele Chiappi Alessio Adamiano Anna Tampieri Weijie Wang Teresa D. Tetley Francesca Buttini Fabio Sonvico Daniele Catalucci Paolo Colombo Michele Iafisco Lorenzo Degli Esposti Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles Journal of Functional Biomaterials hydroxyapatite superparamagnetic nanoparticles nanomedicine microparticles embedding nanoparticles Trojan microparticles pulmonary disease |
| title | Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles |
| title_full | Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles |
| title_fullStr | Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles |
| title_full_unstemmed | Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles |
| title_short | Inhalable Microparticles Embedding Biocompatible Magnetic Iron-Doped Hydroxyapatite Nanoparticles |
| title_sort | inhalable microparticles embedding biocompatible magnetic iron doped hydroxyapatite nanoparticles |
| topic | hydroxyapatite superparamagnetic nanoparticles nanomedicine microparticles embedding nanoparticles Trojan microparticles pulmonary disease |
| url | https://www.mdpi.com/2079-4983/14/4/189 |
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