Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

Abstract Podocyte injury and loss are critical events in diabetic nephropathy (DN); however, the underlying molecular mechanisms remain unclear. Here, we demonstrate that asparaginyl endopeptidase (AEP) protects against podocyte injury through modulating the dynamics of the cytoskeleton. AEP was hig...

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Bibliographic Details
Main Authors: Chuntao Lei, Mengran Li, Yang Qiu, Yaru Xie, Zhe Hao, Xingjie Yin, Zhentao Zhang, Hua Su, Linlin Yang, Jihong Lin, Hans-Peter Hammes, Chun Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04621-2

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