Identifying functional dysregulation of NOD2 variant Q902K in patients with Yao syndrome

Identifying functional dysregulation of NOD2 variant Q902K in patients with Yao syndrome

Abstract Background and objectives The study investigated the pathogenesis of Yao syndrome (YAOS), a rare systemic autoinflammatory disease associated with the nucleotide-binding oligomerization domain containing 2 (NOD2) gene variants. Methods RNA sequencing analyses were used to detect transcripto...

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Bibliographic Details
Main Authors: Jingyuan Zhang, Yi Luo, Bingxuan Wu, Xin Huang, Mengzhu Zhao, Na Wu, Junke Miao, Ji Li, Lei Zhu, Di Wu, Min Shen
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Arthritis Research & Therapy
Subjects:
Yao syndrome
Nucleotide-binding oligomerization domain containing 2 (NOD2)
Pathogenesis
Systemic autoinflammatory diseases
Online Access:https://doi.org/10.1186/s13075-024-03286-w

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