Intestinal permeability in leukemic patients prior to chemotherapy
Objective:The objective of this study was to evaluate the intestinal barrier function in leukemia patients before the start of the chemotherapy with an intestinal permeability test using lactulose and mannitol as markers.Methods:The study enrolled 20 patients diagnosed with leukemia (acute and chron...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-12-01
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| Series: | Revista Brasileira de Hematologia e Hemoterapia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000600409&lng=en&tlng=en |
| _version_ | 1828533362650775552 |
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| author | Juliana Brovini Leite Eduardo Garcia Vilela Henrique Oswaldo da Gama Torres Maria de Lourdes de Abreu Ferrari Aloísio Sales da Cunha |
| author_facet | Juliana Brovini Leite Eduardo Garcia Vilela Henrique Oswaldo da Gama Torres Maria de Lourdes de Abreu Ferrari Aloísio Sales da Cunha |
| author_sort | Juliana Brovini Leite |
| collection | DOAJ |
| description | Objective:The objective of this study was to evaluate the intestinal barrier function in leukemia patients before the start of the chemotherapy with an intestinal permeability test using lactulose and mannitol as markers.Methods:The study enrolled 20 patients diagnosed with leukemia (acute and chronic). Ten healthy volunteers were also submitted to the test as a control group.Results:The median lactulose/mannitol ratio was 0.019 for the Leukemia Patient Group, whereas in healthy controls the median was 0.009 (p-value = 0.244). The median lactulose/mannitol ratio in acute leukemia patients was 0.034 giving a p-value of 0.069 when compared to healthy controls. This same comparison was made between acute myeloid leukemia patients and healthy controls with a p-value of 0.149. There was no significant difference in the intestinal permeability between acute and chronic leukemia patients (p-value = 0.098).Conclusion:The intestinal barrier function measured using the intestinal permeability test was similar in leukemic patients overall and healthy controls, but a tendency toward a different pattern was found in the intestinal barrier function of acute leukemia patients. |
| first_indexed | 2024-12-11T23:08:30Z |
| format | Article |
| id | doaj.art-ed99574f0d374a5198b346474fa757e6 |
| institution | Directory Open Access Journal |
| issn | 1806-0870 |
| language | English |
| last_indexed | 2024-12-11T23:08:30Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-ed99574f0d374a5198b346474fa757e62022-12-22T00:46:49ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1806-08702014-12-0136640941310.1016/j.bjhh.2014.07.007S1516-84842014000600409Intestinal permeability in leukemic patients prior to chemotherapyJuliana Brovini LeiteEduardo Garcia VilelaHenrique Oswaldo da Gama TorresMaria de Lourdes de Abreu FerrariAloísio Sales da CunhaObjective:The objective of this study was to evaluate the intestinal barrier function in leukemia patients before the start of the chemotherapy with an intestinal permeability test using lactulose and mannitol as markers.Methods:The study enrolled 20 patients diagnosed with leukemia (acute and chronic). Ten healthy volunteers were also submitted to the test as a control group.Results:The median lactulose/mannitol ratio was 0.019 for the Leukemia Patient Group, whereas in healthy controls the median was 0.009 (p-value = 0.244). The median lactulose/mannitol ratio in acute leukemia patients was 0.034 giving a p-value of 0.069 when compared to healthy controls. This same comparison was made between acute myeloid leukemia patients and healthy controls with a p-value of 0.149. There was no significant difference in the intestinal permeability between acute and chronic leukemia patients (p-value = 0.098).Conclusion:The intestinal barrier function measured using the intestinal permeability test was similar in leukemic patients overall and healthy controls, but a tendency toward a different pattern was found in the intestinal barrier function of acute leukemia patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000600409&lng=en&tlng=enLeukemiaLactuloseMannitol |
| spellingShingle | Juliana Brovini Leite Eduardo Garcia Vilela Henrique Oswaldo da Gama Torres Maria de Lourdes de Abreu Ferrari Aloísio Sales da Cunha Intestinal permeability in leukemic patients prior to chemotherapy Revista Brasileira de Hematologia e Hemoterapia Leukemia Lactulose Mannitol |
| title | Intestinal permeability in leukemic patients prior to chemotherapy |
| title_full | Intestinal permeability in leukemic patients prior to chemotherapy |
| title_fullStr | Intestinal permeability in leukemic patients prior to chemotherapy |
| title_full_unstemmed | Intestinal permeability in leukemic patients prior to chemotherapy |
| title_short | Intestinal permeability in leukemic patients prior to chemotherapy |
| title_sort | intestinal permeability in leukemic patients prior to chemotherapy |
| topic | Leukemia Lactulose Mannitol |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000600409&lng=en&tlng=en |
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