US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centers
Purpose: Ultrasound-guided high-intensity focused ultrasound (USgHIFU) represents a safe and effective non-invasive thermoablative technique for managing inoperable pancreatic cancer. This treatment method significantly alleviates disease-related symptoms and reduces pancreatic tumor volume. However...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2295812 |
| _version_ | 1826902202914963456 |
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| author | Kun Zhou Holger Strunk Dobromir Dimitrov Joan Vidal-Jove Maria A. Gonzalez-Carmona Markus Essler Chengbin Jin Zhechuan Mei Hui Zhu Milka Marinova |
| author_facet | Kun Zhou Holger Strunk Dobromir Dimitrov Joan Vidal-Jove Maria A. Gonzalez-Carmona Markus Essler Chengbin Jin Zhechuan Mei Hui Zhu Milka Marinova |
| author_sort | Kun Zhou |
| collection | DOAJ |
| description | Purpose: Ultrasound-guided high-intensity focused ultrasound (USgHIFU) represents a safe and effective non-invasive thermoablative technique for managing inoperable pancreatic cancer. This treatment method significantly alleviates disease-related symptoms and reduces pancreatic tumor volume. However, the current body of evidence is constrained by a lack of randomized controlled trials. The utilization of USgHIFU is primarily indicated for patients with unresectable, locally advanced, or metastatic pancreatic cancer, particularly those experiencing symptoms due to a locally advanced primary tumor.Methods: This collaborative consensus paper, involving European and Chinese HIFU centers treating pancreatic cancer, delineates criteria for patient selection, focusing on those most likely to benefit from USgHIFU treatment. Consideration is given to endpoints encompassing symptom alleviation, local response rates, other oncological outcomes, as well as overall and progression-free survival. Additionally, this paper defines relevant contraindications, side effects, and complications associated with USgHIFU. The publication also explores the feasibility and role of USgHIFU within the context of palliative care, including standard systemic chemotherapy.Results: The non-invasive local treatment of advanced pancreatic cancer using HIFU should be regarded as an adjunctive option alongside systemic chemotherapy or best supportive care for managing this aggressive disease. Based on the ability of USgHIFU therapy to mitigate pain and reduce primary tumor volume, it should be considered as a complementary therapy for symptomatic patients with inoperable pancreatic cancer and as a potential means of tumor debulking. The underutilized yet promising USgHIFU exhibits the potential to enhance patients’ quality of life by alleviating cancer-related pain. Experts in the field should evaluate this treatment option be evaluated by experts in this field, with this consensus paper potentially serving as a guiding resource for the medical community.Conclusions: US-guided HIFU for advanced pancreatic cancer addresses treatment goals, available options, success rates, and limitations. As a non-invasive, effective local therapy, complementary to chemotherapy and best supportive care, it plays a pivotal role in pain relief, reducing of tumor volume, and potentially improving survival rates. |
| first_indexed | 2024-03-08T18:20:54Z |
| format | Article |
| id | doaj.art-ed99f216198b4f558ed3f77b112a1989 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2025-02-17T07:36:01Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-ed99f216198b4f558ed3f77b112a19892025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2023.2295812US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centersKun Zhou0Holger Strunk1Dobromir Dimitrov2Joan Vidal-Jove3Maria A. Gonzalez-Carmona4Markus Essler5Chengbin Jin6Zhechuan Mei7Hui Zhu8Milka Marinova9Clinical Center for Tumor Therapy, 2nd Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaMedical Center, Bonn, GermanyDepartment of Surgical Propedeutics, HIFU Center University Hospital St. Marina, Medical University Peleven, Pleven, BulgariaInstitute Khuab, Comprehensive Tumor Center Barcelona, Barcelona, SpainDepartment of Internal Medicine I, University Hospital, Bonn, GermanyDepartment of Nuclear Medicine, University Hospital Bonn, GermanyClinical Center for Tumor Therapy, 2nd Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaDepartment of Gastroenterology and Hepatology, 2nd Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaClinical Center for Tumor Therapy, 2nd Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaDepartment of Nuclear Medicine, University Hospital Bonn, GermanyPurpose: Ultrasound-guided high-intensity focused ultrasound (USgHIFU) represents a safe and effective non-invasive thermoablative technique for managing inoperable pancreatic cancer. This treatment method significantly alleviates disease-related symptoms and reduces pancreatic tumor volume. However, the current body of evidence is constrained by a lack of randomized controlled trials. The utilization of USgHIFU is primarily indicated for patients with unresectable, locally advanced, or metastatic pancreatic cancer, particularly those experiencing symptoms due to a locally advanced primary tumor.Methods: This collaborative consensus paper, involving European and Chinese HIFU centers treating pancreatic cancer, delineates criteria for patient selection, focusing on those most likely to benefit from USgHIFU treatment. Consideration is given to endpoints encompassing symptom alleviation, local response rates, other oncological outcomes, as well as overall and progression-free survival. Additionally, this paper defines relevant contraindications, side effects, and complications associated with USgHIFU. The publication also explores the feasibility and role of USgHIFU within the context of palliative care, including standard systemic chemotherapy.Results: The non-invasive local treatment of advanced pancreatic cancer using HIFU should be regarded as an adjunctive option alongside systemic chemotherapy or best supportive care for managing this aggressive disease. Based on the ability of USgHIFU therapy to mitigate pain and reduce primary tumor volume, it should be considered as a complementary therapy for symptomatic patients with inoperable pancreatic cancer and as a potential means of tumor debulking. The underutilized yet promising USgHIFU exhibits the potential to enhance patients’ quality of life by alleviating cancer-related pain. Experts in the field should evaluate this treatment option be evaluated by experts in this field, with this consensus paper potentially serving as a guiding resource for the medical community.Conclusions: US-guided HIFU for advanced pancreatic cancer addresses treatment goals, available options, success rates, and limitations. As a non-invasive, effective local therapy, complementary to chemotherapy and best supportive care, it plays a pivotal role in pain relief, reducing of tumor volume, and potentially improving survival rates.https://www.tandfonline.com/doi/10.1080/02656736.2023.2295812US-guided HIFUpancreatic cancerexpert consensus |
| spellingShingle | Kun Zhou Holger Strunk Dobromir Dimitrov Joan Vidal-Jove Maria A. Gonzalez-Carmona Markus Essler Chengbin Jin Zhechuan Mei Hui Zhu Milka Marinova US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centers International Journal of Hyperthermia US-guided HIFU pancreatic cancer expert consensus |
| title | US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centers |
| title_full | US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centers |
| title_fullStr | US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centers |
| title_full_unstemmed | US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centers |
| title_short | US-guided high-intensity focused ultrasound in pancreatic cancer treatment: a consensus initiative between Chinese and European HIFU centers |
| title_sort | us guided high intensity focused ultrasound in pancreatic cancer treatment a consensus initiative between chinese and european hifu centers |
| topic | US-guided HIFU pancreatic cancer expert consensus |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2295812 |
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