Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection
Abstract Background Long-acting β2-adrenoceptor agonists have been shown to increase the risk of atrial arrhythmias in patients with stable chronic obstructive pulmonary disease. The aim of this study was to investigate whether perioperative long-acting β2-adrenoceptor agonists treatment would incre...
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | http://link.springer.com/article/10.1186/s13019-017-0606-4 |
| _version_ | 1818846900759035904 |
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| author | Keiji Yamanashi Satoshi Marumo Ryota Sumitomo Tsuyoshi Shoji Motonari Fukui Toshiro Katayama Cheng-long Huang |
| author_facet | Keiji Yamanashi Satoshi Marumo Ryota Sumitomo Tsuyoshi Shoji Motonari Fukui Toshiro Katayama Cheng-long Huang |
| author_sort | Keiji Yamanashi |
| collection | DOAJ |
| description | Abstract Background Long-acting β2-adrenoceptor agonists have been shown to increase the risk of atrial arrhythmias in patients with stable chronic obstructive pulmonary disease. The aim of this study was to investigate whether perioperative long-acting β2-adrenoceptor agonists treatment would increase the risk of postoperative atrial arrhythmias after lung cancer surgery in chronic obstructive pulmonary disease patients. Methods We retrospectively analyzed 174 consecutive chronic obstructive pulmonary disease patients with non-small-cell lung cancer who underwent lobectomy or segmentectomy. The subjects were divided into those with or without perioperative long-acting β2-adrenoceptor agonists treatment. Postoperative cardiopulmonary complications were compared between the two groups. Results There were no statistically significant differences between the perioperative long-acting β2-adrenoceptor agonists treatment group and the control group in the incidence of postoperative atrial arrhythmias (P = 0.629). In 134 propensity-score–matched pairs, including variables such as age, gender, comorbidities, smoking history, operation procedure, lung-cancer staging, and respiratory function, there were no significant differences between the two groups in the incidence of postoperative cardiopulmonary complications, including atrial arrhythmias. Conclusions Perioperative administration of long-acting β2-adrenoceptor agonists might not increase the incidence of postoperative atrial arrhythmias after surgical resection for non-small-cell lung cancer in chronic obstructive pulmonary disease patients. |
| first_indexed | 2024-12-19T05:52:54Z |
| format | Article |
| id | doaj.art-ed9a2a353b7f4c7b8a30f491ccf9c3c8 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-19T05:52:54Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-ed9a2a353b7f4c7b8a30f491ccf9c3c82022-12-21T20:33:34ZengBMCJournal of Cardiothoracic Surgery1749-80902017-05-011211610.1186/s13019-017-0606-4Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resectionKeiji Yamanashi0Satoshi Marumo1Ryota Sumitomo2Tsuyoshi Shoji3Motonari Fukui4Toshiro Katayama5Cheng-long Huang6Department of Thoracic Surgery, Kurashiki Central HospitalRespiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano HospitalRespiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano HospitalDepartment of Thoracic Surgery, Japanese Red Cross Otsu HospitalRespiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano HospitalFaculty of Health Sciences, Department of Medical Engineering, Himeji Dokkyo UniversityRespiratory Disease Center, Tazuke Kofukai Foundation, Medical Research Institute, Kitano HospitalAbstract Background Long-acting β2-adrenoceptor agonists have been shown to increase the risk of atrial arrhythmias in patients with stable chronic obstructive pulmonary disease. The aim of this study was to investigate whether perioperative long-acting β2-adrenoceptor agonists treatment would increase the risk of postoperative atrial arrhythmias after lung cancer surgery in chronic obstructive pulmonary disease patients. Methods We retrospectively analyzed 174 consecutive chronic obstructive pulmonary disease patients with non-small-cell lung cancer who underwent lobectomy or segmentectomy. The subjects were divided into those with or without perioperative long-acting β2-adrenoceptor agonists treatment. Postoperative cardiopulmonary complications were compared between the two groups. Results There were no statistically significant differences between the perioperative long-acting β2-adrenoceptor agonists treatment group and the control group in the incidence of postoperative atrial arrhythmias (P = 0.629). In 134 propensity-score–matched pairs, including variables such as age, gender, comorbidities, smoking history, operation procedure, lung-cancer staging, and respiratory function, there were no significant differences between the two groups in the incidence of postoperative cardiopulmonary complications, including atrial arrhythmias. Conclusions Perioperative administration of long-acting β2-adrenoceptor agonists might not increase the incidence of postoperative atrial arrhythmias after surgical resection for non-small-cell lung cancer in chronic obstructive pulmonary disease patients.http://link.springer.com/article/10.1186/s13019-017-0606-4Lung cancer surgeryLong-acting β2-adrenoceptor agonistsPostoperative respiratory complications |
| spellingShingle | Keiji Yamanashi Satoshi Marumo Ryota Sumitomo Tsuyoshi Shoji Motonari Fukui Toshiro Katayama Cheng-long Huang Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection Journal of Cardiothoracic Surgery Lung cancer surgery Long-acting β2-adrenoceptor agonists Postoperative respiratory complications |
| title | Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection |
| title_full | Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection |
| title_fullStr | Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection |
| title_full_unstemmed | Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection |
| title_short | Long acting β2-adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection |
| title_sort | long acting β2 adrenocepter agonists are not associated with atrial arrhythmias after pulmonary resection |
| topic | Lung cancer surgery Long-acting β2-adrenoceptor agonists Postoperative respiratory complications |
| url | http://link.springer.com/article/10.1186/s13019-017-0606-4 |
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