Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy

Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy

Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent patients characterized by high risk of metastatic progression and recurrence after therapy. Effective therapeutic management of this disease still remains elusive as evidenced by poor patient survival rates. To achie...

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Bibliographic Details
Main Authors: Francesca Cersosimo, Silvia Lonardi, Giulia Bernardini, Brian Telfer, Giulio Eugenio Mandelli, Annalisa Santucci, William Vermi, Emanuele Giurisato
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
tumor-associated macrophages (TAMs)
osteosarcomas (OSs)
metastasis
cancer-stem cells
mesenchymal stem cells
tumor microenvironment
Online Access:https://www.mdpi.com/1422-0067/21/15/5207

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