Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source
Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-01-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/1/167 |
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| author | Hou-Jin Li Wen-Han Jiang Wan-Ling Liang Jia-Xin Huang Yu-Fei Mo Yan-Qing Ding Chi-Keung Lam Xiao-Jun Qian Xiao-Feng Zhu Wen-Jian Lan |
| author_facet | Hou-Jin Li Wen-Han Jiang Wan-Ling Liang Jia-Xin Huang Yu-Fei Mo Yan-Qing Ding Chi-Keung Lam Xiao-Jun Qian Xiao-Feng Zhu Wen-Jian Lan |
| author_sort | Hou-Jin Li |
| collection | DOAJ |
| description | Chondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM. |
| first_indexed | 2024-04-11T22:47:38Z |
| format | Article |
| id | doaj.art-ed9c143fee144bae940a31b435f8545c |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:47:38Z |
| publishDate | 2014-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ed9c143fee144bae940a31b435f8545c2022-12-22T03:58:43ZengMDPI AGMarine Drugs1660-33972014-01-0112116717510.3390/md12010167md12010167Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon SourceHou-Jin Li0Wen-Han Jiang1Wan-Ling Liang2Jia-Xin Huang3Yu-Fei Mo4Yan-Qing Ding5Chi-Keung Lam6Xiao-Jun Qian7Xiao-Feng Zhu8Wen-Jian Lan9School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaSchool of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaSchool of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, ChinaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, ChinaSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, ChinaChondrostereum sp., a marine fungus isolated from a soft coral Sarcophyton tortuosum, can yield hirsutane framework sesquiterpenoids. However, the metabolites profiles vary dramatically with the composition change of the culture media. This fungus was cultured in a liquid medium containing glycerol as the carbon source, and two new metabolites, chondrosterins I and J (1 and 2), were obtained. Their structures were elucidated primarily based on MS, NMR and X-ray single-crystal diffraction data. By comparison with the known hirsutane sesquiterpenoids, chondrosterins I and J have unique structural features, including a methyl was migrated from C-2 to C-6, and the methyl at C-3 was carboxylated. Compound 2 exhibited potent cytotoxic activities against the cancer cell lines CNE-1 and CNE-2 with the IC50 values of 1.32 and 0.56 μM.http://www.mdpi.com/1660-3397/12/1/167marine fungusChondrostereum sp.sesquiterpenoidschondrosterinscytotoxic activity |
| spellingShingle | Hou-Jin Li Wen-Han Jiang Wan-Ling Liang Jia-Xin Huang Yu-Fei Mo Yan-Qing Ding Chi-Keung Lam Xiao-Jun Qian Xiao-Feng Zhu Wen-Jian Lan Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source Marine Drugs marine fungus Chondrostereum sp. sesquiterpenoids chondrosterins cytotoxic activity |
| title | Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source |
| title_full | Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source |
| title_fullStr | Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source |
| title_full_unstemmed | Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source |
| title_short | Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source |
| title_sort | induced marine fungus chondrostereum sp as a means of producing new sesquiterpenoids chondrosterins i and j by using glycerol as the carbon source |
| topic | marine fungus Chondrostereum sp. sesquiterpenoids chondrosterins cytotoxic activity |
| url | http://www.mdpi.com/1660-3397/12/1/167 |
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