Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World Management
<i>Background and Objectives</i>: It is well established that patients with peripheral artery disease (PAD) as well abdominal aortic aneurysm (AAA) have an increased cardiovascular (CV) mortality. Despite this higher risk, PAD and AAA patients are often suboptimality treated. This study...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/7/672 |
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| author | Francesco Natale Raffaele Capasso Alfonso Casalino Clotilde Crescenzi Paolo Sangiuolo Paolo Golino Francesco S. Loffredo Giovanni Cimmino |
| author_facet | Francesco Natale Raffaele Capasso Alfonso Casalino Clotilde Crescenzi Paolo Sangiuolo Paolo Golino Francesco S. Loffredo Giovanni Cimmino |
| author_sort | Francesco Natale |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: It is well established that patients with peripheral artery disease (PAD) as well abdominal aortic aneurysm (AAA) have an increased cardiovascular (CV) mortality. Despite this higher risk, PAD and AAA patients are often suboptimality treated. This study assessed the CV profile of PAD and AAA patients, quantifying the survival benefits of target-based risk-factors modification even in light of the COVID-19 pandemic. <i>Materials and Methods</i>: PAD and AAA patients admitted for any reason to the Vascular Unit from January 2019 to February 2020 were retrospectively analyzed. Biochemical and CV profiles as well as ongoing medical therapies were recorded. Benefits of CV risk-factors control were estimated using the SMART-REACH model. A follow-up visit during the year 2020 was scheduled. <i>Results</i>: A total of 669 patients were included. Of these, 190 showed AAA and 479 PAD at any stage. Only 54% of PAD and 41% of AAA patients were on lipid-lowering drugs with non-optimal low-density lipoprotein (LDL) levels for most of them. A better control of all modifiable CV risk-factors based on the current guidelines would offer an absolute risk reduction of the mean 10-year CV risk by 9% in PAD and 14% in AAA. Unfortunately, the follow-up visit was lost because of COVID-19 limitations. <i>Conclusions</i>: Lipid profiles of PAD and AAA patients were far from guideline-based targets, and medical management was suboptimal. In our center, the COVID-19 pandemic impacted on the strict surveillance required in these very high-risk patients. The achievement of guideline-based therapeutic targets would definitively confer additional significant benefits in reducing the CV risk in these patients. |
| first_indexed | 2024-03-10T09:59:12Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T09:59:12Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-ed9f9a88091f4123b61dad931472e1ae2023-11-22T02:07:57ZengMDPI AGMedicina1010-660X1648-91442021-06-0157767210.3390/medicina57070672Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World ManagementFrancesco Natale0Raffaele Capasso1Alfonso Casalino2Clotilde Crescenzi3Paolo Sangiuolo4Paolo Golino5Francesco S. Loffredo6Giovanni Cimmino7Vanvitelli Cardiology and Intensive Care Unit, Monaldi Hospital, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Section of Cardiology, University of Campania “Luigi Vanvitelli”, 80131 Naples, ItalyVascular Surgery Unit, Monaldi Hospital, 80131 Naples, ItalyVascular Surgery Unit, Monaldi Hospital, 80131 Naples, ItalyVascular Surgery Unit, Monaldi Hospital, 80131 Naples, ItalyVanvitelli Cardiology and Intensive Care Unit, Monaldi Hospital, 80131 Naples, ItalyVanvitelli Cardiology and Intensive Care Unit, Monaldi Hospital, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Section of Cardiology, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy<i>Background and Objectives</i>: It is well established that patients with peripheral artery disease (PAD) as well abdominal aortic aneurysm (AAA) have an increased cardiovascular (CV) mortality. Despite this higher risk, PAD and AAA patients are often suboptimality treated. This study assessed the CV profile of PAD and AAA patients, quantifying the survival benefits of target-based risk-factors modification even in light of the COVID-19 pandemic. <i>Materials and Methods</i>: PAD and AAA patients admitted for any reason to the Vascular Unit from January 2019 to February 2020 were retrospectively analyzed. Biochemical and CV profiles as well as ongoing medical therapies were recorded. Benefits of CV risk-factors control were estimated using the SMART-REACH model. A follow-up visit during the year 2020 was scheduled. <i>Results</i>: A total of 669 patients were included. Of these, 190 showed AAA and 479 PAD at any stage. Only 54% of PAD and 41% of AAA patients were on lipid-lowering drugs with non-optimal low-density lipoprotein (LDL) levels for most of them. A better control of all modifiable CV risk-factors based on the current guidelines would offer an absolute risk reduction of the mean 10-year CV risk by 9% in PAD and 14% in AAA. Unfortunately, the follow-up visit was lost because of COVID-19 limitations. <i>Conclusions</i>: Lipid profiles of PAD and AAA patients were far from guideline-based targets, and medical management was suboptimal. In our center, the COVID-19 pandemic impacted on the strict surveillance required in these very high-risk patients. The achievement of guideline-based therapeutic targets would definitively confer additional significant benefits in reducing the CV risk in these patients.https://www.mdpi.com/1648-9144/57/7/672cardiovascular riskperipheral artery diseaseabdominal aortic aneurysmlipid profileCOVID-19 |
| spellingShingle | Francesco Natale Raffaele Capasso Alfonso Casalino Clotilde Crescenzi Paolo Sangiuolo Paolo Golino Francesco S. Loffredo Giovanni Cimmino Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World Management Medicina cardiovascular risk peripheral artery disease abdominal aortic aneurysm lipid profile COVID-19 |
| title | Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World Management |
| title_full | Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World Management |
| title_fullStr | Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World Management |
| title_full_unstemmed | Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World Management |
| title_short | Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World Management |
| title_sort | peripheral artery disease and abdominal aortic aneurysm the forgotten diseases in covid 19 pandemic results from an observational study on real world management |
| topic | cardiovascular risk peripheral artery disease abdominal aortic aneurysm lipid profile COVID-19 |
| url | https://www.mdpi.com/1648-9144/57/7/672 |
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