FokI polymorphism of the vitamin D receptor is closely related to a reduced insulin sensitivity in healthy adults
Summary: Background & aims: The “TT” genotype of the FokI polymorphism (rs2228570; T>C) of the vitamin D receptor has previously been associated with a higher risk of insulin resistance, metabolic syndrome and diabetes. The objective of this study was to compare the insulin sensitivity b...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Clinical Nutrition Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268522000493 |
| _version_ | 1811237721012699136 |
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| author | Benjamín Armando Núñez-García Jorge Maldonado-Hernández Nelson Eduardo Álvarez-Licona María Elizabeth Tejero-Barrera Mariela Bernabe-García Alva Belen Morales-Villar Leticia Sebastián-Medina Mónica Ivette Piña-Aguero Juan Manuel Domínguez-Salgado |
| author_facet | Benjamín Armando Núñez-García Jorge Maldonado-Hernández Nelson Eduardo Álvarez-Licona María Elizabeth Tejero-Barrera Mariela Bernabe-García Alva Belen Morales-Villar Leticia Sebastián-Medina Mónica Ivette Piña-Aguero Juan Manuel Domínguez-Salgado |
| author_sort | Benjamín Armando Núñez-García |
| collection | DOAJ |
| description | Summary: Background & aims: The “TT” genotype of the FokI polymorphism (rs2228570; T>C) of the vitamin D receptor has previously been associated with a higher risk of insulin resistance, metabolic syndrome and diabetes. The objective of this study was to compare the insulin sensitivity between the different genotypes of the FokI polymorphism after an oral glucose tolerance test (OGTT) in healthy adults. Methods: thirty-three previously genotyped subjects were selected randomly. Three groups of eleven participants were formed according to the allelic variants of the FokI polymorphism: “CC”, “CT” and “TT”. An oral glucose tolerance test was administrated and blood samples were drawn at baseline, 10, 20, 30, 60, 90, 120, 150 and 180 minutes. Plasma glucose, insulin and vitamin D concentrations were determined. Two OGTT derived indexes were computed: the Matsuda-DeFronzo insulin sensitivity index and an insulinogenic index. Results: no significant differences among study groups were found in any of the anthropometric and metabolic features, neither in vitamin D concentrations. Carriers of the “TT” genotype showed a substantial significant reduction of insulin sensitivity (≈40%) in contrast with the “CC+CT” group. Additionally, an inverse association was observed between the insulin sensitivity index and the number of copies of the “T” allele at 120 and 180 minutes (rho=-0.359, P=0.040; rho=-0.355, P=0.043, respectively). In contrast, no associations were found between any of the genotype models and the insulinogenic index. Conclusion: our results demonstrate a substantial reduction of insulin sensitivity in the carriers of the “TT” genotype. Since this decrement was observed in young non-obese subjects, the presence of the “TT” genotype suggests a considerable risk of impaired glucose metabolism in the carriers of this allelic variant. |
| first_indexed | 2024-04-12T12:29:19Z |
| format | Article |
| id | doaj.art-eda1f77574c54a3bb95a68dad9efd397 |
| institution | Directory Open Access Journal |
| issn | 2667-2685 |
| language | English |
| last_indexed | 2024-04-12T12:29:19Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj.art-eda1f77574c54a3bb95a68dad9efd3972022-12-22T03:33:05ZengElsevierClinical Nutrition Open Science2667-26852022-10-0145103111FokI polymorphism of the vitamin D receptor is closely related to a reduced insulin sensitivity in healthy adultsBenjamín Armando Núñez-García0Jorge Maldonado-Hernández1Nelson Eduardo Álvarez-Licona2María Elizabeth Tejero-Barrera3Mariela Bernabe-García4Alva Belen Morales-Villar5Leticia Sebastián-Medina6Mónica Ivette Piña-Aguero7Juan Manuel Domínguez-Salgado8Unit of Research in Medical Nutrition, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro Social. Av. Cuauhtémoc No. 330, Col. Doctores, Mexico City, MexicoUnit of Research in Medical Nutrition, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro Social. Av. Cuauhtémoc No. 330, Col. Doctores, Mexico City, Mexico; Corresponding author. Av. Cuauhtémoc No. 330, Col. Doctores, Mexico City, ZIP 06720, Mexico. Tel./fax: +52 55 56 27 69 44.Graduate Department, Escuela Superior de Medicina, Instituto Politécnico Nacional. Salvador Díaz Mirón esq. Plan de San Luis S/N, Col. Casco de Santo Tomas, Mexico City, MexicoNutrigenomics and Nutrigenetics Laboratory, Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Mexico City, MexicoUnit of Research in Medical Nutrition, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro Social. Av. Cuauhtémoc No. 330, Col. Doctores, Mexico City, MexicoUnit of Research in Medical Nutrition, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro Social. Av. Cuauhtémoc No. 330, Col. Doctores, Mexico City, MexicoNutrigenomics and Nutrigenetics Laboratory, Instituto Nacional de Medicina Genómica, Periférico Sur No. 4809, Col. Arenal Tepepan, Mexico City, MexicoUnit of Research in Medical Nutrition, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro Social. Av. Cuauhtémoc No. 330, Col. Doctores, Mexico City, MexicoUnit of Research in Medical Nutrition, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro Social. Av. Cuauhtémoc No. 330, Col. Doctores, Mexico City, MexicoSummary: Background & aims: The “TT” genotype of the FokI polymorphism (rs2228570; T>C) of the vitamin D receptor has previously been associated with a higher risk of insulin resistance, metabolic syndrome and diabetes. The objective of this study was to compare the insulin sensitivity between the different genotypes of the FokI polymorphism after an oral glucose tolerance test (OGTT) in healthy adults. Methods: thirty-three previously genotyped subjects were selected randomly. Three groups of eleven participants were formed according to the allelic variants of the FokI polymorphism: “CC”, “CT” and “TT”. An oral glucose tolerance test was administrated and blood samples were drawn at baseline, 10, 20, 30, 60, 90, 120, 150 and 180 minutes. Plasma glucose, insulin and vitamin D concentrations were determined. Two OGTT derived indexes were computed: the Matsuda-DeFronzo insulin sensitivity index and an insulinogenic index. Results: no significant differences among study groups were found in any of the anthropometric and metabolic features, neither in vitamin D concentrations. Carriers of the “TT” genotype showed a substantial significant reduction of insulin sensitivity (≈40%) in contrast with the “CC+CT” group. Additionally, an inverse association was observed between the insulin sensitivity index and the number of copies of the “T” allele at 120 and 180 minutes (rho=-0.359, P=0.040; rho=-0.355, P=0.043, respectively). In contrast, no associations were found between any of the genotype models and the insulinogenic index. Conclusion: our results demonstrate a substantial reduction of insulin sensitivity in the carriers of the “TT” genotype. Since this decrement was observed in young non-obese subjects, the presence of the “TT” genotype suggests a considerable risk of impaired glucose metabolism in the carriers of this allelic variant.http://www.sciencedirect.com/science/article/pii/S2667268522000493VDRInsulin sensitivityFokI polymorphismOGTTISI-Composite |
| spellingShingle | Benjamín Armando Núñez-García Jorge Maldonado-Hernández Nelson Eduardo Álvarez-Licona María Elizabeth Tejero-Barrera Mariela Bernabe-García Alva Belen Morales-Villar Leticia Sebastián-Medina Mónica Ivette Piña-Aguero Juan Manuel Domínguez-Salgado FokI polymorphism of the vitamin D receptor is closely related to a reduced insulin sensitivity in healthy adults Clinical Nutrition Open Science VDR Insulin sensitivity FokI polymorphism OGTT ISI-Composite |
| title | FokI polymorphism of the vitamin D receptor is closely related to a reduced insulin sensitivity in healthy adults |
| title_full | FokI polymorphism of the vitamin D receptor is closely related to a reduced insulin sensitivity in healthy adults |
| title_fullStr | FokI polymorphism of the vitamin D receptor is closely related to a reduced insulin sensitivity in healthy adults |
| title_full_unstemmed | FokI polymorphism of the vitamin D receptor is closely related to a reduced insulin sensitivity in healthy adults |
| title_short | FokI polymorphism of the vitamin D receptor is closely related to a reduced insulin sensitivity in healthy adults |
| title_sort | foki polymorphism of the vitamin d receptor is closely related to a reduced insulin sensitivity in healthy adults |
| topic | VDR Insulin sensitivity FokI polymorphism OGTT ISI-Composite |
| url | http://www.sciencedirect.com/science/article/pii/S2667268522000493 |
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