Clinical-grade human skin-derived ABCB5+ mesenchymal stromal cells exert anti-apoptotic and anti-inflammatory effects in vitro and modulate mRNA expression in a cisplatin-induced kidney injury murine model

Clinical-grade human skin-derived ABCB5+ mesenchymal stromal cells exert anti-apoptotic and anti-inflammatory effects in vitro and modulate mRNA expression in a cisplatin-induced kidney injury murine model

Acute kidney injury (AKI) is characterized by a rapid reduction in renal function and glomerular filtration rate (GFR). The broadly used anti-cancer chemotherapeutic agent cisplatin often induces AKI as an adverse drug side effect. Therapies targeted at the reversal of AKI and its potential progress...

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Bibliographic Details
Main Authors: Erika Rendra, Adriana Torres Crigna, Cristina Daniele, Carsten Sticht, Maike Cueppers, Mark Andreas Kluth, Christoph Ganss, Markus H. Frank, Norbert Gretz, Karen Bieback
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stromal cells
ABCB5
cisplatin
kidney injury
PBMC
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1228928/full

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