XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study
Abstract Background X‐ray repair cross‐complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene‐environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 po...
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Wiley
2021-04-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.3847 |
| _version_ | 1818662657574567936 |
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| author | Li‐Xiang Yu Li‐Yuan Liu Yu‐Juan Xiang Fei Wang Fei Zhou Shu‐Ya Huang Chao Zheng Chun‐Miao Ye Wen‐Zhong Zhou Geng‐Shen Yin Jia‐Lin Zhang Shu‐De Cui Fu‐Guo Tian Zhi‐Min Fan Cui‐Zhi Geng Xu‐Chen Cao Zhen‐Lin Yang Xiang Wang Hong Liang Shu Wang Hong‐Chuan Jiang Xue‐Ning Duan Hai‐Bo Wang Guo‐Lou Li Qi‐Tang Wang Jian‐Guo Zhang Feng Jin Jin‐Hai Tang Liang Li Shi‐Guang Zhu Wen‐Shu Zuo Zhong‐Bing Ma Zhi‐Gang Yu |
| author_facet | Li‐Xiang Yu Li‐Yuan Liu Yu‐Juan Xiang Fei Wang Fei Zhou Shu‐Ya Huang Chao Zheng Chun‐Miao Ye Wen‐Zhong Zhou Geng‐Shen Yin Jia‐Lin Zhang Shu‐De Cui Fu‐Guo Tian Zhi‐Min Fan Cui‐Zhi Geng Xu‐Chen Cao Zhen‐Lin Yang Xiang Wang Hong Liang Shu Wang Hong‐Chuan Jiang Xue‐Ning Duan Hai‐Bo Wang Guo‐Lou Li Qi‐Tang Wang Jian‐Guo Zhang Feng Jin Jin‐Hai Tang Liang Li Shi‐Guang Zhu Wen‐Shu Zuo Zhong‐Bing Ma Zhi‐Gang Yu |
| author_sort | Li‐Xiang Yu |
| collection | DOAJ |
| description | Abstract Background X‐ray repair cross‐complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene‐environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction. Methods The study included 1039 patients with breast cancer and 1040 controls. Four single‐nucleotide polymorphisms of XRCC5 and two of XRCC6 were genotyped. Information about smoking, alcohol consumption, and sleep satisfaction was collected through questionnaires. Odds ratios (OR) and related 95% confidence intervals (95% CI) were assessed using unconditional logistic regression models. Gene‐environment interactions were analyzed using logistic regression with multiplicative interaction models. Results XRCC5 rs16855458 was associated with increased breast cancer risk in the co‐dominant (ptrend = 0.003) and dominant (CA + AA vs. CC, OR = 1.29, 95% CI = 1.07–1.56, p = 0.008) genetic models after Bonferroni correction. The CG + GG genotype of XRCC6 rs2267437 was associated with an increased risk of estrogen receptor‐negative/progesterone receptor‐negative (ER−/PR−) breast cancer (CG + GG vs. CC: OR = 1.54, 95% CI = 1.12–2.13, p = 0.008) after Bonferroni correction. Moreover, an antagonistic interaction between XRCC5 rs16855458 and alcohol consumption (pinteraction = 0.017), and a synergistic interaction between XRCC6 rs2267437 and sleep satisfaction were associated with breast cancer risk (pinteraction = 0.0497). However, these interactions became insignificant after Bonferroni correction. Conclusion XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER−/PR− breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation. |
| first_indexed | 2024-12-17T05:04:26Z |
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| language | English |
| last_indexed | 2024-12-17T05:04:26Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
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| series | Cancer Medicine |
| spelling | doaj.art-eda38974bb294977b8b116605d71e23e2022-12-21T22:02:28ZengWileyCancer Medicine2045-76342021-04-011082752276210.1002/cam4.3847XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center studyLi‐Xiang Yu0Li‐Yuan Liu1Yu‐Juan Xiang2Fei Wang3Fei Zhou4Shu‐Ya Huang5Chao Zheng6Chun‐Miao Ye7Wen‐Zhong Zhou8Geng‐Shen Yin9Jia‐Lin Zhang10Shu‐De Cui11Fu‐Guo Tian12Zhi‐Min Fan13Cui‐Zhi Geng14Xu‐Chen Cao15Zhen‐Lin Yang16Xiang Wang17Hong Liang18Shu Wang19Hong‐Chuan Jiang20Xue‐Ning Duan21Hai‐Bo Wang22Guo‐Lou Li23Qi‐Tang Wang24Jian‐Guo Zhang25Feng Jin26Jin‐Hai Tang27Liang Li28Shi‐Guang Zhu29Wen‐Shu Zuo30Zhong‐Bing Ma31Zhi‐Gang Yu32Department of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery Affiliated Tumor Hospital of Zhengzhou University Zhengzhou ChinaDepartment of Breast Surgery Shanxi Cancer Hospital Taiyuan ChinaDepartment of Breast Surgery The First Hospital of Jilin University Changchun ChinaDepartment of Breast Center The Fourth Hospital of Hebei Medical University Shijiazhuang ChinaDepartment of Breast Surgery Tianjin Medical University Cancer Institute and Hospital Tianjin ChinaDepartment of Thyroid and Breast Surgery The First Affiliated Hospital of Binzhou Medical University Binzhou ChinaDepartment of Breast Surgery Cancer HospitalChinese Academy of Medical Sciences Beijing ChinaDepartment of General Surgery Linyi People's Hospital Linyi ChinaDepartment of Breast Disease Center Peking University People's Hospital Beijing ChinaDepartment of General Surgery Beijing Chaoyang Hospital Beijing ChinaDepartment of Breast Disease Center Peking University First Hospital Beijing ChinaDepartment of Breast Center Qingdao University Affiliated Hospital Qingdao ChinaDepartment of Breast and Thyroid Surgery Weifang Traditional Chinese Hospital Weifang ChinaDepartment of Breast Surgery Qingdao Central Hospital Qingdao ChinaDepartment of General Surgery The Second Affiliated Hospital of Harbin Medical University Harbin ChinaDepartment of Breast Surgery The First Affiliated Hospital of China Medical University Shenyang ChinaDepartment of General Surgery Nanjing Medical University Affiliated Cancer HospitalCancer Institute of Jiangsu Province Nanjing ChinaDepartment of Breast and Thyroid Surgery Zibo Central Hospital Zibo ChinaDepartment of Breast Surgery Yantai Yuhuangding Hospital Yantai ChinaDepartment of Breast Cancer Center Shandong Cancer Hospital Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaDepartment of Breast Surgery The Second HospitalCheeloo College of MedicineShandong University Jinan ChinaAbstract Background X‐ray repair cross‐complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene‐environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction. Methods The study included 1039 patients with breast cancer and 1040 controls. Four single‐nucleotide polymorphisms of XRCC5 and two of XRCC6 were genotyped. Information about smoking, alcohol consumption, and sleep satisfaction was collected through questionnaires. Odds ratios (OR) and related 95% confidence intervals (95% CI) were assessed using unconditional logistic regression models. Gene‐environment interactions were analyzed using logistic regression with multiplicative interaction models. Results XRCC5 rs16855458 was associated with increased breast cancer risk in the co‐dominant (ptrend = 0.003) and dominant (CA + AA vs. CC, OR = 1.29, 95% CI = 1.07–1.56, p = 0.008) genetic models after Bonferroni correction. The CG + GG genotype of XRCC6 rs2267437 was associated with an increased risk of estrogen receptor‐negative/progesterone receptor‐negative (ER−/PR−) breast cancer (CG + GG vs. CC: OR = 1.54, 95% CI = 1.12–2.13, p = 0.008) after Bonferroni correction. Moreover, an antagonistic interaction between XRCC5 rs16855458 and alcohol consumption (pinteraction = 0.017), and a synergistic interaction between XRCC6 rs2267437 and sleep satisfaction were associated with breast cancer risk (pinteraction = 0.0497). However, these interactions became insignificant after Bonferroni correction. Conclusion XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER−/PR− breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation.https://doi.org/10.1002/cam4.3847alcohol consumptionbreast cancergene‐environment interactionsleep satisfactionsmokingXRCC5 |
| spellingShingle | Li‐Xiang Yu Li‐Yuan Liu Yu‐Juan Xiang Fei Wang Fei Zhou Shu‐Ya Huang Chao Zheng Chun‐Miao Ye Wen‐Zhong Zhou Geng‐Shen Yin Jia‐Lin Zhang Shu‐De Cui Fu‐Guo Tian Zhi‐Min Fan Cui‐Zhi Geng Xu‐Chen Cao Zhen‐Lin Yang Xiang Wang Hong Liang Shu Wang Hong‐Chuan Jiang Xue‐Ning Duan Hai‐Bo Wang Guo‐Lou Li Qi‐Tang Wang Jian‐Guo Zhang Feng Jin Jin‐Hai Tang Liang Li Shi‐Guang Zhu Wen‐Shu Zuo Zhong‐Bing Ma Zhi‐Gang Yu XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study Cancer Medicine alcohol consumption breast cancer gene‐environment interaction sleep satisfaction smoking XRCC5 |
| title | XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study |
| title_full | XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study |
| title_fullStr | XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study |
| title_full_unstemmed | XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study |
| title_short | XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study |
| title_sort | xrcc5 6 polymorphisms and their interactions with smoking alcohol consumption and sleep satisfaction in breast cancer risk a chinese multi center study |
| topic | alcohol consumption breast cancer gene‐environment interaction sleep satisfaction smoking XRCC5 |
| url | https://doi.org/10.1002/cam4.3847 |
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