Oxidative Stress and Human Ovarian Response—From Somatic Ovarian Cells to Oocytes Damage: A Clinical Comprehensive Narrative Review
Basic scientific research on human reproduction and oxidative damage has been extensively performed; however, a more clinical view is still lacking. As a result, exhaustive data on the influence of oxidative stress on human ovarian response and, consequently, on fertility are still lacking. This nar...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/7/1335 |
| _version_ | 1797407739673051136 |
|---|---|
| author | Valentina Immediata Camilla Ronchetti Daria Spadaro Federico Cirillo Paolo Emanuele Levi-Setti |
| author_facet | Valentina Immediata Camilla Ronchetti Daria Spadaro Federico Cirillo Paolo Emanuele Levi-Setti |
| author_sort | Valentina Immediata |
| collection | DOAJ |
| description | Basic scientific research on human reproduction and oxidative damage has been extensively performed; however, a more clinical view is still lacking. As a result, exhaustive data on the influence of oxidative stress on human ovarian response and, consequently, on fertility are still lacking. This narrative review aims at summarizing the role of oxidative stress in different conditions associated to female infertility and to list some of the main antioxidant agents. A systematic literature search was performed in May 2022 to retrieve studies regarding the oxidative stress and the human ovarian response from somatic ovarian cells to oocytes damage. Only human studies were included and the authors focused their review, in particular, on clinical implications in order to define a new research perspective on the assessment of any eventual strategy to preserve women’s fertility. Thereby, the authors evaluated the contribution of DNA repair pathways in improving women’s fertility by reducing the DNA damage associated with aging or diseases, such as endometriosis or polycystic ovary syndrome, and eventually, in prolonging the reproductive lifespan after cancer treatment. |
| first_indexed | 2024-03-09T03:46:56Z |
| format | Article |
| id | doaj.art-eda3908a1c0949b49752ad3fd889c554 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T03:46:56Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-eda3908a1c0949b49752ad3fd889c5542023-12-03T14:34:02ZengMDPI AGAntioxidants2076-39212022-07-01117133510.3390/antiox11071335Oxidative Stress and Human Ovarian Response—From Somatic Ovarian Cells to Oocytes Damage: A Clinical Comprehensive Narrative ReviewValentina Immediata0Camilla Ronchetti1Daria Spadaro2Federico Cirillo3Paolo Emanuele Levi-Setti4Division of Gynecology and Reproductive Medicine, Fertility Center, Department of Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Fertility Center, Department of Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, ItalyDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Fertility Center, Department of Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, ItalyDivision of Gynecology and Reproductive Medicine, Fertility Center, Department of Gynecology, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, ItalyBasic scientific research on human reproduction and oxidative damage has been extensively performed; however, a more clinical view is still lacking. As a result, exhaustive data on the influence of oxidative stress on human ovarian response and, consequently, on fertility are still lacking. This narrative review aims at summarizing the role of oxidative stress in different conditions associated to female infertility and to list some of the main antioxidant agents. A systematic literature search was performed in May 2022 to retrieve studies regarding the oxidative stress and the human ovarian response from somatic ovarian cells to oocytes damage. Only human studies were included and the authors focused their review, in particular, on clinical implications in order to define a new research perspective on the assessment of any eventual strategy to preserve women’s fertility. Thereby, the authors evaluated the contribution of DNA repair pathways in improving women’s fertility by reducing the DNA damage associated with aging or diseases, such as endometriosis or polycystic ovary syndrome, and eventually, in prolonging the reproductive lifespan after cancer treatment.https://www.mdpi.com/2076-3921/11/7/1335oxidative stressoocyte qualityantioxidantsreactive oxygen specieswomen’s fertility |
| spellingShingle | Valentina Immediata Camilla Ronchetti Daria Spadaro Federico Cirillo Paolo Emanuele Levi-Setti Oxidative Stress and Human Ovarian Response—From Somatic Ovarian Cells to Oocytes Damage: A Clinical Comprehensive Narrative Review Antioxidants oxidative stress oocyte quality antioxidants reactive oxygen species women’s fertility |
| title | Oxidative Stress and Human Ovarian Response—From Somatic Ovarian Cells to Oocytes Damage: A Clinical Comprehensive Narrative Review |
| title_full | Oxidative Stress and Human Ovarian Response—From Somatic Ovarian Cells to Oocytes Damage: A Clinical Comprehensive Narrative Review |
| title_fullStr | Oxidative Stress and Human Ovarian Response—From Somatic Ovarian Cells to Oocytes Damage: A Clinical Comprehensive Narrative Review |
| title_full_unstemmed | Oxidative Stress and Human Ovarian Response—From Somatic Ovarian Cells to Oocytes Damage: A Clinical Comprehensive Narrative Review |
| title_short | Oxidative Stress and Human Ovarian Response—From Somatic Ovarian Cells to Oocytes Damage: A Clinical Comprehensive Narrative Review |
| title_sort | oxidative stress and human ovarian response from somatic ovarian cells to oocytes damage a clinical comprehensive narrative review |
| topic | oxidative stress oocyte quality antioxidants reactive oxygen species women’s fertility |
| url | https://www.mdpi.com/2076-3921/11/7/1335 |
| work_keys_str_mv | AT valentinaimmediata oxidativestressandhumanovarianresponsefromsomaticovariancellstooocytesdamageaclinicalcomprehensivenarrativereview AT camillaronchetti oxidativestressandhumanovarianresponsefromsomaticovariancellstooocytesdamageaclinicalcomprehensivenarrativereview AT dariaspadaro oxidativestressandhumanovarianresponsefromsomaticovariancellstooocytesdamageaclinicalcomprehensivenarrativereview AT federicocirillo oxidativestressandhumanovarianresponsefromsomaticovariancellstooocytesdamageaclinicalcomprehensivenarrativereview AT paoloemanuelelevisetti oxidativestressandhumanovarianresponsefromsomaticovariancellstooocytesdamageaclinicalcomprehensivenarrativereview |