Long-term efficacy of HDM-SCIT in pediatric and adult patients with allergic rhinitis
Abstract Background Subcutaneous immunotherapy (SCIT) is a well-validated and effective disease modification treatment for house dust mites (HDM)-induced allergic rhinitis (AR). Long-term post-treatment comparisons in children and adults treated with SCIT have rarely been published. This study aimed...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | https://doi.org/10.1186/s13223-023-00781-8 |
| _version_ | 1827983822293041152 |
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| author | Lei Ren Chengshuo Wang Lin Xi Yunbo Gao Yuan Zhang Luo Zhang |
| author_facet | Lei Ren Chengshuo Wang Lin Xi Yunbo Gao Yuan Zhang Luo Zhang |
| author_sort | Lei Ren |
| collection | DOAJ |
| description | Abstract Background Subcutaneous immunotherapy (SCIT) is a well-validated and effective disease modification treatment for house dust mites (HDM)-induced allergic rhinitis (AR). Long-term post-treatment comparisons in children and adults treated with SCIT have rarely been published. This study aimed to evaluate the long-term efficacy of HDM-SCIT administered under a cluster schedule in children compared to adults. Methods This was an open-design, observational, long-term clinical follow-up study on children and adults with perennial AR treated with HDM-SCIT. The follow-up consisted of a three-year treatment duration plus a post-treatment follow-up of over three years. Results Patients in the pediatric (n = 58) and adult (n = 103) groups completed a post-SCIT follow-up of over three years. The total nasal symptom score (TNSS), combined symptom medication score (CSMS), and rhinoconjunctivitis quality-of-life questionnaire (RQLQ) score decreased significantly at T1 (three-year SCIT completed) and T2 (follow-up completed) in the pediatric and adult groups. In both groups, the improvement rate of TNSS (T0-T1) was moderately correlated with the baseline TNSS (r = 0.681, p < 0.001 and r = 0.477, p < 0.001 for children and adults, respectively). Only in the pediatric group, TNSS was significantly lower at T2 compared with that right after SCIT cessation (T1) (p = 0.030). Conclusions Children and adults with HDM-induced perennial AR could achieve a sustainable post-treatment efficacy for over three years (up to 13 years) following a three-year SCIT. Patients with relatively severe nasal symptoms at baseline may benefit more from SCIT. Children who have completed an adequate course of SCIT may gain further improvement in nasal symptoms after SCIT cessation. |
| first_indexed | 2024-04-09T22:52:18Z |
| format | Article |
| id | doaj.art-eda4a3f9b12d41b09208b0a6db4d04c4 |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-04-09T22:52:18Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-eda4a3f9b12d41b09208b0a6db4d04c42023-03-22T11:36:07ZengBMCAllergy, Asthma & Clinical Immunology1710-14922023-03-011911910.1186/s13223-023-00781-8Long-term efficacy of HDM-SCIT in pediatric and adult patients with allergic rhinitisLei Ren0Chengshuo Wang1Lin Xi2Yunbo Gao3Yuan Zhang4Luo Zhang5Department of Allergy, Beijing TongRen Hospital, Capital Medical UniversityDepartment of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical UniversityDepartment of Allergy, Beijing TongRen Hospital, Capital Medical UniversityDepartment of Allergy, Beijing TongRen Hospital, Capital Medical UniversityDepartment of Allergy, Beijing TongRen Hospital, Capital Medical UniversityDepartment of Allergy, Beijing TongRen Hospital, Capital Medical UniversityAbstract Background Subcutaneous immunotherapy (SCIT) is a well-validated and effective disease modification treatment for house dust mites (HDM)-induced allergic rhinitis (AR). Long-term post-treatment comparisons in children and adults treated with SCIT have rarely been published. This study aimed to evaluate the long-term efficacy of HDM-SCIT administered under a cluster schedule in children compared to adults. Methods This was an open-design, observational, long-term clinical follow-up study on children and adults with perennial AR treated with HDM-SCIT. The follow-up consisted of a three-year treatment duration plus a post-treatment follow-up of over three years. Results Patients in the pediatric (n = 58) and adult (n = 103) groups completed a post-SCIT follow-up of over three years. The total nasal symptom score (TNSS), combined symptom medication score (CSMS), and rhinoconjunctivitis quality-of-life questionnaire (RQLQ) score decreased significantly at T1 (three-year SCIT completed) and T2 (follow-up completed) in the pediatric and adult groups. In both groups, the improvement rate of TNSS (T0-T1) was moderately correlated with the baseline TNSS (r = 0.681, p < 0.001 and r = 0.477, p < 0.001 for children and adults, respectively). Only in the pediatric group, TNSS was significantly lower at T2 compared with that right after SCIT cessation (T1) (p = 0.030). Conclusions Children and adults with HDM-induced perennial AR could achieve a sustainable post-treatment efficacy for over three years (up to 13 years) following a three-year SCIT. Patients with relatively severe nasal symptoms at baseline may benefit more from SCIT. Children who have completed an adequate course of SCIT may gain further improvement in nasal symptoms after SCIT cessation.https://doi.org/10.1186/s13223-023-00781-8Allergic rhinitisEfficacyLong-termPediatricSubcutaneous immunotherapy |
| spellingShingle | Lei Ren Chengshuo Wang Lin Xi Yunbo Gao Yuan Zhang Luo Zhang Long-term efficacy of HDM-SCIT in pediatric and adult patients with allergic rhinitis Allergy, Asthma & Clinical Immunology Allergic rhinitis Efficacy Long-term Pediatric Subcutaneous immunotherapy |
| title | Long-term efficacy of HDM-SCIT in pediatric and adult patients with allergic rhinitis |
| title_full | Long-term efficacy of HDM-SCIT in pediatric and adult patients with allergic rhinitis |
| title_fullStr | Long-term efficacy of HDM-SCIT in pediatric and adult patients with allergic rhinitis |
| title_full_unstemmed | Long-term efficacy of HDM-SCIT in pediatric and adult patients with allergic rhinitis |
| title_short | Long-term efficacy of HDM-SCIT in pediatric and adult patients with allergic rhinitis |
| title_sort | long term efficacy of hdm scit in pediatric and adult patients with allergic rhinitis |
| topic | Allergic rhinitis Efficacy Long-term Pediatric Subcutaneous immunotherapy |
| url | https://doi.org/10.1186/s13223-023-00781-8 |
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