Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia
Masho Tigabe,1 Abaynesh Fentahun,1 Solomon Getawa,2 Kassahun Alemu Gelaye,3 Eyob Alemayehu Gebreyohannes1,4 1Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Hematology and Immunohematology, School of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-09-01
|
| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/clinical-characteristics-and-in-hospital-outcome-of-acute-heart-failur-peer-reviewed-fulltext-article-VHRM |
| _version_ | 1818912621818019840 |
|---|---|
| author | Tigabe M Fentahun A Getawa S Gelaye KA Gebreyohannes EA |
| author_facet | Tigabe M Fentahun A Getawa S Gelaye KA Gebreyohannes EA |
| author_sort | Tigabe M |
| collection | DOAJ |
| description | Masho Tigabe,1 Abaynesh Fentahun,1 Solomon Getawa,2 Kassahun Alemu Gelaye,3 Eyob Alemayehu Gebreyohannes1,4 1Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 4Division of Pharmacy, School of Allied Health, University of Western Australia, Nedlands, AustraliaCorrespondence: Solomon GetawaDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, EthiopiaTel +251 914-665-736Email solomon2525geta@gmail.comBackground: Despite the growing burden of heart failure in developing countries, data describing the clinical characteristics and in-hospital outcomes of acute heart failures are limited. Therefore, this study aimed at describing the clinical characteristics and in-hospital outcomes of acute heart failure patients admitted to the medical ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.Methods: A prospective observational hospital-based cross-sectional study was conducted on 226 patients with acute heart failure at the University of Gondar Comprehensive Specialized Hospital from November 2019 to October 2020. Data were collected by using a pretested data abstraction format and analyzed with Statistical Package for Social Sciences version 21. Bivariable and multivariable binary logistic regression model were fitted to identify factors associated with in-hospital outcome and reported with 95% confidence interval (CI). P-value < 0.05 was considered as statistically significant.Results: The mean (± standard deviation) age of the study participant was 51.17± 19.03 years and 59.3% were females. Majority, 60.6% of patients were admitted with new onset heart failure. Dyspnea (88.05%) and peripheral edema (80.5%) were the most frequent clinical findings. The in-hospital mortality was 10.6% (95% CI: 7.1– 14.7). Atrial fibrillation (AOR=9.46; 95% CI: 1.49– 60.29), concurrent ischemic heart disease (AOR=8.23; 95% CI: 1.15– 58.89), being admitted with reduced left ventricular ejection fraction (AOR=5.36; 95% CI: 2.81– 35.52), presence of orthopnea (AOR=6.63; 95% CI: 2.94– 46.76), and using intranasal oxygen therapy (AOR=9.41; 95% CI: 1.35– 65.82) were significantly associated with in-hospital mortality in patients with acute heart failure.Conclusion: The in-hospital mortality of acute heart failure patients was relatively higher in the study area. Therefore, specific preventative and therapeutic strategies focusing on heart failure patients with reduced left ventricular ejection fraction, atrial fibrillation, ischemic heart disease, orthopnea, and intranasal oxygen therapy are required to reduce the mortality rate.Keywords: heart failure, clinical characteristics, in-hospital mortality, Ethiopia |
| first_indexed | 2024-12-19T23:17:31Z |
| format | Article |
| id | doaj.art-eda4e73c5c924431b1c15d4c9cc7f93b |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-19T23:17:31Z |
| publishDate | 2021-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-eda4e73c5c924431b1c15d4c9cc7f93b2022-12-21T20:02:04ZengDove Medical PressVascular Health and Risk Management1178-20482021-09-01Volume 1758159068880Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest EthiopiaTigabe MFentahun AGetawa SGelaye KAGebreyohannes EAMasho Tigabe,1 Abaynesh Fentahun,1 Solomon Getawa,2 Kassahun Alemu Gelaye,3 Eyob Alemayehu Gebreyohannes1,4 1Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 4Division of Pharmacy, School of Allied Health, University of Western Australia, Nedlands, AustraliaCorrespondence: Solomon GetawaDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, EthiopiaTel +251 914-665-736Email solomon2525geta@gmail.comBackground: Despite the growing burden of heart failure in developing countries, data describing the clinical characteristics and in-hospital outcomes of acute heart failures are limited. Therefore, this study aimed at describing the clinical characteristics and in-hospital outcomes of acute heart failure patients admitted to the medical ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.Methods: A prospective observational hospital-based cross-sectional study was conducted on 226 patients with acute heart failure at the University of Gondar Comprehensive Specialized Hospital from November 2019 to October 2020. Data were collected by using a pretested data abstraction format and analyzed with Statistical Package for Social Sciences version 21. Bivariable and multivariable binary logistic regression model were fitted to identify factors associated with in-hospital outcome and reported with 95% confidence interval (CI). P-value < 0.05 was considered as statistically significant.Results: The mean (± standard deviation) age of the study participant was 51.17± 19.03 years and 59.3% were females. Majority, 60.6% of patients were admitted with new onset heart failure. Dyspnea (88.05%) and peripheral edema (80.5%) were the most frequent clinical findings. The in-hospital mortality was 10.6% (95% CI: 7.1– 14.7). Atrial fibrillation (AOR=9.46; 95% CI: 1.49– 60.29), concurrent ischemic heart disease (AOR=8.23; 95% CI: 1.15– 58.89), being admitted with reduced left ventricular ejection fraction (AOR=5.36; 95% CI: 2.81– 35.52), presence of orthopnea (AOR=6.63; 95% CI: 2.94– 46.76), and using intranasal oxygen therapy (AOR=9.41; 95% CI: 1.35– 65.82) were significantly associated with in-hospital mortality in patients with acute heart failure.Conclusion: The in-hospital mortality of acute heart failure patients was relatively higher in the study area. Therefore, specific preventative and therapeutic strategies focusing on heart failure patients with reduced left ventricular ejection fraction, atrial fibrillation, ischemic heart disease, orthopnea, and intranasal oxygen therapy are required to reduce the mortality rate.Keywords: heart failure, clinical characteristics, in-hospital mortality, Ethiopiahttps://www.dovepress.com/clinical-characteristics-and-in-hospital-outcome-of-acute-heart-failur-peer-reviewed-fulltext-article-VHRMheart failureclinical characteristicsin-hospital mortalityethiopia |
| spellingShingle | Tigabe M Fentahun A Getawa S Gelaye KA Gebreyohannes EA Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia Vascular Health and Risk Management heart failure clinical characteristics in-hospital mortality ethiopia |
| title | Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_full | Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_fullStr | Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_full_unstemmed | Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_short | Clinical Characteristics and In-Hospital Outcome of Acute Heart Failure Patients Admitted to the Medical Ward of University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia |
| title_sort | clinical characteristics and in hospital outcome of acute heart failure patients admitted to the medical ward of university of gondar comprehensive specialized hospital northwest ethiopia |
| topic | heart failure clinical characteristics in-hospital mortality ethiopia |
| url | https://www.dovepress.com/clinical-characteristics-and-in-hospital-outcome-of-acute-heart-failur-peer-reviewed-fulltext-article-VHRM |
| work_keys_str_mv | AT tigabem clinicalcharacteristicsandinhospitaloutcomeofacuteheartfailurepatientsadmittedtothemedicalwardofuniversityofgondarcomprehensivespecializedhospitalnorthwestethiopia AT fentahuna clinicalcharacteristicsandinhospitaloutcomeofacuteheartfailurepatientsadmittedtothemedicalwardofuniversityofgondarcomprehensivespecializedhospitalnorthwestethiopia AT getawas clinicalcharacteristicsandinhospitaloutcomeofacuteheartfailurepatientsadmittedtothemedicalwardofuniversityofgondarcomprehensivespecializedhospitalnorthwestethiopia AT gelayeka clinicalcharacteristicsandinhospitaloutcomeofacuteheartfailurepatientsadmittedtothemedicalwardofuniversityofgondarcomprehensivespecializedhospitalnorthwestethiopia AT gebreyohannesea clinicalcharacteristicsandinhospitaloutcomeofacuteheartfailurepatientsadmittedtothemedicalwardofuniversityofgondarcomprehensivespecializedhospitalnorthwestethiopia |