Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica.

Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica.

BACKGROUND: Neuromyelitis optica (NMO), a severe demyelinating disease, represents itself with optic neuritis and longitudinally extensive transverse myelitis. Serum NMO-IgG autoantibodies (Abs), a specific finding in NMO patients, target the water channel protein aquaporin-4 (AQP4), which is expres...

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Main Authors: Simone Mader, Andreas Lutterotti, Franziska Di Pauli, Bettina Kuenz, Kathrin Schanda, Fahmy Aboul-Enein, Michael Khalil, Maria K Storch, Sven Jarius, Wolfgang Kristoferitsch, Thomas Berger, Markus Reindl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2864757?pdf=render

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