Hypermethylation and reduced expression of Gtl2, Rian and Mirg at the Dlk1-Dio3 imprinted locus as a marker for poor developmental potential of mouse embryonic stem cells

Hypermethylation and reduced expression of Gtl2, Rian and Mirg at the Dlk1-Dio3 imprinted locus as a marker for poor developmental potential of mouse embryonic stem cells

Mouse embryonic stem cells (ESCs) have played a crucial role in biomedical research where they can be used to elucidate gene function through the generation of genetically modified mice. A critical requirement for the success of this technology is the ability of ESCs to contribute to viable chimaera...

Full description

Bibliographic Details
Main Authors: Maria Schacker, Yi-Han Cheng, Melanie Eckersley-Maslin, Richard Michael Snaith, William Henry Colledge
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Stem Cell Research
Subjects:
Embryonic stem cells
Epigenomics
Gene expression
Embryonic development
Methylation
Imprinting
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120302324

Similar Items

Similar Items