Plant Derived Natural Products against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Antibiofilm Activity and Molecular Mechanisms
Bacteria are social organisms able to build complex structures, such as biofilms, that are highly organized surface-associated communities of microorganisms, encased within a self- produced extracellular matrix. Biofilm is commonly associated with many health problems since its formation increases r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/21/5024 |
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| author | Francesca Guzzo Monica Scognamiglio Antonio Fiorentino Elisabetta Buommino Brigida D’Abrosca |
| author_facet | Francesca Guzzo Monica Scognamiglio Antonio Fiorentino Elisabetta Buommino Brigida D’Abrosca |
| author_sort | Francesca Guzzo |
| collection | DOAJ |
| description | Bacteria are social organisms able to build complex structures, such as biofilms, that are highly organized surface-associated communities of microorganisms, encased within a self- produced extracellular matrix. Biofilm is commonly associated with many health problems since its formation increases resistance to antibiotics and antimicrobial agents, as in the case of <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>, two human pathogens causing major concern. <i>P. aeruginosa</i> is responsible for severe nosocomial infections, the most frequent of which is ventilator-associated pneumonia, while <i>S. aureus</i> causes several problems, like skin infections, septic arthritis, and endocarditis, to name just a few. Literature data suggest that natural products from plants, bacteria, fungi, and marine organisms have proven to be effective as anti-biofilm agents, inhibiting the formation of the polymer matrix, suppressing cell adhesion and attachment, and decreasing the virulence factors’ production, thereby blocking the quorum sensing network. Here, we focus on plant derived chemicals, and provide an updated literature review on the anti-biofilm properties of terpenes, flavonoids, alkaloids, and phenolic compounds. Moreover, whenever information is available, we also report the mechanisms of action. |
| first_indexed | 2024-03-10T15:14:23Z |
| format | Article |
| id | doaj.art-eda72e5be14c43be88dfb03bd21408c9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:14:23Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-eda72e5be14c43be88dfb03bd21408c92023-11-20T19:05:16ZengMDPI AGMolecules1420-30492020-10-012521502410.3390/molecules25215024Plant Derived Natural Products against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Antibiofilm Activity and Molecular MechanismsFrancesca Guzzo0Monica Scognamiglio1Antonio Fiorentino2Elisabetta Buommino3Brigida D’Abrosca4Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche–DiSTABiF, Università degli Studi della Campania “Luigi Vanvitelli”, via Vivaldi 43, I-81100 Caserta, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche–DiSTABiF, Università degli Studi della Campania “Luigi Vanvitelli”, via Vivaldi 43, I-81100 Caserta, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche–DiSTABiF, Università degli Studi della Campania “Luigi Vanvitelli”, via Vivaldi 43, I-81100 Caserta, ItalyDipartimento di Farmacia, Università degli Studi di Napoli “Federico II”, Via Domenico Montesano 49, 80131 Napoli, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche–DiSTABiF, Università degli Studi della Campania “Luigi Vanvitelli”, via Vivaldi 43, I-81100 Caserta, ItalyBacteria are social organisms able to build complex structures, such as biofilms, that are highly organized surface-associated communities of microorganisms, encased within a self- produced extracellular matrix. Biofilm is commonly associated with many health problems since its formation increases resistance to antibiotics and antimicrobial agents, as in the case of <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>, two human pathogens causing major concern. <i>P. aeruginosa</i> is responsible for severe nosocomial infections, the most frequent of which is ventilator-associated pneumonia, while <i>S. aureus</i> causes several problems, like skin infections, septic arthritis, and endocarditis, to name just a few. Literature data suggest that natural products from plants, bacteria, fungi, and marine organisms have proven to be effective as anti-biofilm agents, inhibiting the formation of the polymer matrix, suppressing cell adhesion and attachment, and decreasing the virulence factors’ production, thereby blocking the quorum sensing network. Here, we focus on plant derived chemicals, and provide an updated literature review on the anti-biofilm properties of terpenes, flavonoids, alkaloids, and phenolic compounds. Moreover, whenever information is available, we also report the mechanisms of action.https://www.mdpi.com/1420-3049/25/21/5024plant-derived natural productsterpenesflavonoidsantibiotic-resistancebiofilmquorum sensing |
| spellingShingle | Francesca Guzzo Monica Scognamiglio Antonio Fiorentino Elisabetta Buommino Brigida D’Abrosca Plant Derived Natural Products against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Antibiofilm Activity and Molecular Mechanisms Molecules plant-derived natural products terpenes flavonoids antibiotic-resistance biofilm quorum sensing |
| title | Plant Derived Natural Products against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Antibiofilm Activity and Molecular Mechanisms |
| title_full | Plant Derived Natural Products against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Antibiofilm Activity and Molecular Mechanisms |
| title_fullStr | Plant Derived Natural Products against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Antibiofilm Activity and Molecular Mechanisms |
| title_full_unstemmed | Plant Derived Natural Products against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Antibiofilm Activity and Molecular Mechanisms |
| title_short | Plant Derived Natural Products against <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i>: Antibiofilm Activity and Molecular Mechanisms |
| title_sort | plant derived natural products against i pseudomonas aeruginosa i and i staphylococcus aureus i antibiofilm activity and molecular mechanisms |
| topic | plant-derived natural products terpenes flavonoids antibiotic-resistance biofilm quorum sensing |
| url | https://www.mdpi.com/1420-3049/25/21/5024 |
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