High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster
Pre-existing comorbidities such as obesity or metabolic diseases can adversely affect the clinical outcome of COVID-19. Chronic metabolic disorders are globally on the rise and often a consequence of an unhealthy diet, referred to as a Western Diet. For the first time in the Syrian hamster model, we...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/12/2506 |
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| author | Julia R. Port Danielle R. Adney Benjamin Schwarz Jonathan E. Schulz Daniel E. Sturdevant Brian J. Smith Victoria A. Avanzato Myndi G. Holbrook Jyothi N. Purushotham Kaitlin A. Stromberg Ian Leighton Catharine M. Bosio Carl Shaia Vincent J. Munster |
| author_facet | Julia R. Port Danielle R. Adney Benjamin Schwarz Jonathan E. Schulz Daniel E. Sturdevant Brian J. Smith Victoria A. Avanzato Myndi G. Holbrook Jyothi N. Purushotham Kaitlin A. Stromberg Ian Leighton Catharine M. Bosio Carl Shaia Vincent J. Munster |
| author_sort | Julia R. Port |
| collection | DOAJ |
| description | Pre-existing comorbidities such as obesity or metabolic diseases can adversely affect the clinical outcome of COVID-19. Chronic metabolic disorders are globally on the rise and often a consequence of an unhealthy diet, referred to as a Western Diet. For the first time in the Syrian hamster model, we demonstrate the detrimental impact of a continuous high-fat high-sugar diet on COVID-19 outcome. We observed increased weight loss and lung pathology, such as exudate, vasculitis, hemorrhage, fibrin, and edema, delayed viral clearance and functional lung recovery, and prolonged viral shedding. This was accompanied by an altered, but not significantly different, systemic IL-10 and IL-6 profile, as well as a dysregulated serum lipid response dominated by polyunsaturated fatty acid-containing phosphatidylethanolamine, partially recapitulating cytokine and lipid responses associated with severe human COVID-19. Our data support the hamster model for testing restrictive or targeted diets and immunomodulatory therapies to mediate the adverse effects of metabolic disease on COVID-19. |
| first_indexed | 2024-03-10T03:54:38Z |
| format | Article |
| id | doaj.art-eda73c54589548a29b44fc9e99783875 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T03:54:38Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-eda73c54589548a29b44fc9e997838752023-11-23T10:58:53ZengMDPI AGViruses1999-49152021-12-011312250610.3390/v13122506High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian HamsterJulia R. Port0Danielle R. Adney1Benjamin Schwarz2Jonathan E. Schulz3Daniel E. Sturdevant4Brian J. Smith5Victoria A. Avanzato6Myndi G. Holbrook7Jyothi N. Purushotham8Kaitlin A. Stromberg9Ian Leighton10Catharine M. Bosio11Carl Shaia12Vincent J. Munster13Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USAGenomics Unit, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USARocky Mountain Veterinary Branch, Division of Intramural Research, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USARocky Mountain Veterinary Branch, Division of Intramural Research, National Institutes of Health, Hamilton, MT 59840, USALaboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USAPre-existing comorbidities such as obesity or metabolic diseases can adversely affect the clinical outcome of COVID-19. Chronic metabolic disorders are globally on the rise and often a consequence of an unhealthy diet, referred to as a Western Diet. For the first time in the Syrian hamster model, we demonstrate the detrimental impact of a continuous high-fat high-sugar diet on COVID-19 outcome. We observed increased weight loss and lung pathology, such as exudate, vasculitis, hemorrhage, fibrin, and edema, delayed viral clearance and functional lung recovery, and prolonged viral shedding. This was accompanied by an altered, but not significantly different, systemic IL-10 and IL-6 profile, as well as a dysregulated serum lipid response dominated by polyunsaturated fatty acid-containing phosphatidylethanolamine, partially recapitulating cytokine and lipid responses associated with severe human COVID-19. Our data support the hamster model for testing restrictive or targeted diets and immunomodulatory therapies to mediate the adverse effects of metabolic disease on COVID-19.https://www.mdpi.com/1999-4915/13/12/2506Syrian hamsterSARS-CoV-2obesitypathogenesislipid metabolism |
| spellingShingle | Julia R. Port Danielle R. Adney Benjamin Schwarz Jonathan E. Schulz Daniel E. Sturdevant Brian J. Smith Victoria A. Avanzato Myndi G. Holbrook Jyothi N. Purushotham Kaitlin A. Stromberg Ian Leighton Catharine M. Bosio Carl Shaia Vincent J. Munster High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster Viruses Syrian hamster SARS-CoV-2 obesity pathogenesis lipid metabolism |
| title | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
| title_full | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
| title_fullStr | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
| title_full_unstemmed | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
| title_short | High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster |
| title_sort | high fat high sugar diet induced changes in the lipid metabolism are associated with mildly increased covid 19 severity and delayed recovery in the syrian hamster |
| topic | Syrian hamster SARS-CoV-2 obesity pathogenesis lipid metabolism |
| url | https://www.mdpi.com/1999-4915/13/12/2506 |
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